Results 131 to 140 of about 687,543 (306)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Identification of Dietary Patterns Among Women Undergoing Assisted Reproduction and Its Association with Reproductive Outcomes

International Journal of Women's Health
Rongyan Zhang,* Shengnan Cong,* Jing Zhao,* Yuxuan Wu, Yueyue Cai, Linhong Li Department of Reproductive Medicine, Women’s Hospital of Nanjing Medical University (Nanjing Women and Children’s Healthcare Hospital), Nanjing, People ...
Zhang R, Cong S, Zhao J, Wu Y, Cai Y, Li L   +5 more
doaj  

Actuarial Senescence In A Dimorphic Bird: Different Rates Of Ageing In Morphs With Discrete Reproductive Strategies [PDF]

, 2018
It is often hypothesized that intra-sexual competition accelerates actuarial senescence, or the increase in mortality rates with age. However, an alternative hypothesis is that parental investment is more important to determining senescence rates.
Barcelo-Serra, M., Betuel, A. M., Formica, Vincent A., Gonser, R. A., Grunst, A. S., Grunst, M. L., Korody, M. L., Tuttle, E. M.   +7 more
core   +1 more source

A note on pattern reproduction in tessellation structures

Journal of Computer and System Sciences, 1978
AbstractTessellation structures that reproduce arbitrary patterns are special cases of tessellation structures having local transformations that are linear operators. We introduce a novel formulation of tessellation structures which emphasizes the connection between these structures and concepts of functional analysis.
openaire   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Outstanding intraindividual genetic diversity in fissiparous planarians (Dugesia, Platyhelminthes) with facultative sex.

, 2019
Predicted genetic consequences of asexuality include high intraindividual genetic diversity (i.e., the Meselson effect) and accumulation of deleterious mutations (i.e., Muller’s Ratchet), among others.
Leria, L., Riutort, M., Solà, E., Vila Farre, M.   +3 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Sexual reproductive cycle and gametogenesis in sea anemones (Cnidaria: Anthozoa): a scope review

Ocean and Coastal Research
Sea anemones have a wide range of reproductive modes, which may contribute to their broad distribution. Understanding reproductive traits and patterns, such as seasonality, is important to elucidate the evolutionary processes that shaped the current ...
Rafael A. Brandão, Yago A. de Melo, Carlos D. Perez, Paula B. Gomes   +3 more
doaj   +1 more source

Partial baldness in relation to reproduction in pond bats in the Netherlands [PDF]

, 2009
Meervleermuizen (Myotis dasycneme) vertonen vaak opvallende kale plekken op de rug. Aan de hand van data van meer dan 2200 gevangen meervleermuizen tussen 2003 en 2008 hebben we de mogelijke sociale, eologische en fysiologische oorzaken achter dit ...
Alphen, J., van, Haarsma, A.J.
core   +1 more source