Results 121 to 130 of about 5,851,498 (298)

Knowledge of the Ovulatory Period and Associated Factors Among Reproductive Women in Ethiopia: A Population-Based Study Using the 2016 Ethiopian Demographic Health Survey

International Journal of Women's Health, 2020
Melaku Bimerew Getahun, Addisu Getie Nigatu Department of Nursing, College of Health Sciences, Woldia University, Woldia, EthiopiaCorrespondence: Melaku Bimerew Getahun Tel +251923065826Email mebiget@gmail.comPurpose: In the era of increasing health ...
Getahun MB, Nigatu AG
doaj  

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Freedom for some, but not for Mum: the reproductive injustice associated with pandemic ‘Freedom Day’ for perinatal women in the United Kingdom

Frontiers in Public Health
IntroductionHealthcare services for pregnant and postpartum (‘perinatal’) women were reconfigured significantly at the advent and for the duration of the SARS-CoV-2 pandemic, and despite the United Kingdom announcing ‘Freedom Day’ on 19 July 2021 ...
Sergio A. Silverio, Sergio A. Silverio, Elizabeth J. Harris, Leanne Jackson, Victoria Fallon, The PRaM Study Group, Abigail Easter, Peter von Dadelszen, Davor Jurković, Laura A. Magee, Laura K. Soulsby, Paul Christiansen, Leonardo De Pascalis, Joanne A. Harrold   +13 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

The accumulation of Microcystin-LR in the gonads of Pelophylax nigromaculatus during the reproductive periods induces reproductive endocrine disorders in their offspring

Ecotoxicology and Environmental Safety
Microcystin-LR’s reproductive (reproductive and non-reproductive periods) and transgenerational toxicity in amphibians remains poorly understood. Adult Pelophylax nigromaculatus in reproductive and non-reproductive periods were exposed to MC-LR to ...
Huijuan Zhang, Yuefei Ruan, Zifang Ding, Zheng Li, Jun He, Jing Li, Pei Hong, Hailong Wu, Yilin Shu   +8 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Post-placental intrauterine device: expanding access to reproductive health in an African province

Annals of Medicine
Background Angola has scarce availability of contraceptive methods; the use of post-placental copper intrauterine device (PPIUD) is restricted due to lack of training among professionals and knowledge among women.
Maria de Lourdes Paulo Dias, José Paulo Guida, Thuany Bento Herculano, Belmiro Gonçalves Pereira, Fernanda Garanhani Surita   +4 more
doaj   +1 more source