Results 151 to 160 of about 1,102,149 (353)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Effect of GnRH treatment as a potential solution for ovarian disorders in dairy cows infected with foot and mouth disease in Indonesian smallholder farms

Open Veterinary Journal
Background: The outbreak of foot and mouth disease (FMD) in Indonesia induces reproductive disorders in dairy cows that lead to economic losses to smallholder dairy farms.
Joko Susilo, Erif Maha Nugraha Setyawan, Slamet Hartanto, Michael Haryadi Wibowo, Agung Budiyanto   +4 more
doaj   +1 more source

Contraceptive prevalence rate in women of reproductive age in a semi urban community of Islamabad

, 2019
Umme Kulsoom Khattak, Saima Perwaiz Iqbal, Ahmed Abdullah, Ayesha Chowhan   +3 more
openalex   +2 more sources

Growth rate mediates hidden developmental plasticity of female yellow dung fly reproductive morphology in response to environmental stressors

, 2022
Richard J. Walters, David Berger, Wolf U. Blanckenhorn, Luc F. Bussière, Patrick T. Rohner, Ralf Jochmann, Karin Thüler, Martin A. Schäfer   +7 more
openalex   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

The effect of growth rate on reproductive outcomes in replacement dairy heifers in seasonally calving, pasture-based systems [PDF]

, 2019
Ciara J. Hayes, Conor G. McAloon, Catherine Carty, Eoin G. Ryan, John F. Mee, Luke O’Grady   +5 more
openalex   +1 more source

A surplus no more? Variation in krill availability impacts reproductive rates of Antarctic baleen whales [PDF]

, 2023
Logan J. Pallin, Nick Kellar, Debbie Steel, Natalia Botero‐Acosta, C. Scott Baker, John A. Conroy, Daniel P. Costa, Christopher M. Johnson, David W. Johnston, Ross Nichols, Doug P. Nowacek, Andrew J. Read, O. Savenko, Oscar Schofield, Sharon Stammerjohn, Deborah K. Steinberg, Ari S. Friedlaender   +16 more
openalex   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Global properties of an age-structured virus model with saturated antibody immune response, multi-target cells and general incidence rate

, 2017
Some viruses, such as human immunodeficiency virus, can infect several types of cell populations. The age of infection can also affect the dynamics of infected cells and production of viral particles.
Cervantes-Pérez, Ángel, Ávila-Vales, Eric   +1 more
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source