Results 191 to 200 of about 537,641 (265)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Endometrial Preparation Strategies for Frozen Embryo Transfer in Women with Adenomyosis: A Systematic Review of Hormone Replacement Therapy, Gonadotropin-Releasing Hormone Agonist, and Oxytocin Antagonists. [PDF]

Int J Womens Health
Christina NLL, Tjahyadi D, Anwar R, Rachmawati A.   +3 more
europepmc   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Seasonal Variation of Gut Bacterial Community in Wild <i>Apodemus agrarius</i> Is Associated With Intrinsic and Extrinsic Environments. [PDF]

Ecol Evol
Zhang Y, Chen Y, Bai Z, Zhang X, Wang D.
europepmc   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Patency, Pregnancy, and Live Birth Outcomes of Microsurgical Vasovasostomy Com-pared with Vasoepididymostomy for Vasectomy Reversal: A Systematic Review and Me-ta-Analysis. [PDF]

Int Braz J Urol
Alhanifa AF, Mahapradana PT, Artawan PKA, Negara MO, Duarsa GWK.   +4 more
europepmc   +1 more source

Fertility in Ethiopia: factors associated with the number of live births -a survey-adjusted poisson regression analysis of the 2019 ethiopian mini demographic and health survey. [PDF]

Front Reprod Health
Mesfin MD, Wondu AY, Galgalo DA, Atmaca L, Buda Á, Prémusz V.   +5 more
europepmc   +1 more source

High sperm DNA fragmentation is associated with increased embryonic chromosomal abnormality: a retrospective study of 8 years involving 5637 couples undergoing ART. [PDF]

Hum Reprod Open
Lou L, Xu P, Xie P, Zhang H, Gu Y, Gong F, Lin G, Lu G, Dai J, Ma S.   +9 more
europepmc   +1 more source

Endocrine, Metabolic, and Reproductive Responses to Bee Pollen Supplementation During Seasonal Anestrus in Goats in a Time-Dependent Manner. [PDF]

Biology (Basel)
Rojas A, Sims RN, Bruner BL, Olanrewaju AA, Cavazos-Galindo JM, Cuevas-Reyes V, Ghaffari MH, Rosales-Nieto CA.   +7 more
europepmc   +1 more source