Results 231 to 240 of about 1,102,149 (353)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Application of unsupervised learning to cluster swine breeding herds based on key performance indicators in Southern Brazil. [PDF]

Transl Anim Sci
Ulguim RR, Pereira MA, Tavares J, Linhares DCL, Mellagi APG, Bortolozzo FP, Tecchio CA, Nagae RY, Cavazini NC, de Lara AC, Silva GS.   +10 more
europepmc   +1 more source

Association Between State Policies on Improving Opioid Prescribing in 2 States and Opioid Overdose Rates Among Reproductive-aged Women

, 2020
Xu Ji, Sarah C. Haight, Jean Y. Ko, Shanna Cox, Wanda D. Barfield, Kun Zhang, Gery P. Guy, Rui Li   +7 more
openalex   +2 more sources

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Importance of Social Hierarchy in Morphometry, and Socio-Sexual and Reproductive Behaviors in Dorper Sheep in Northern Mexico. [PDF]

Animals (Basel)
Moreno-Avalos S, Gaytan-Aguilera MA, Zuñiga-Serrano A, Véliz-Romero FG, Díaz-Rojas E, Rodríguez-Martínez R, Contreras-Villarreal V, Legarreta-González MA, Navarrete-Molina C, Véliz-Deras FG.   +9 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Wanted: A population genetic theory of biological noise regulation. [PDF]

PLoS Genet
Weinreich DM, Sgouros T, Raynes Y, Burtsev H, Chang E, Rajakumar S, Bravo IG, Petak C.   +7 more
europepmc   +1 more source

[Sperm donation utilization rates in nonobstructive azoospermia patients under different testicular sperm retrieval methods during assisted reproductive technology cycles].

Qian Chen, Yidong Chen, Zhi‐Jie Zheng, Wenhao Tang, Zhengwen Liu, Kai Hong, Haodong Lin   +6 more
openalex   +2 more sources

Appendix A. Mathematical derivations of R0 (the basic reproductive rate of the pathogen) for the nonseasonal model.

, 2016
Anna M. Fabiszewski, James Umbanhowar, Charles E. Mitchell   +2 more
openalex   +1 more source