Results 131 to 140 of about 51,339 (313)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Out-of-pocket payment for assisted reproductive techniques in the public health sector in South Africa - how do households cope?

, 2011
Includes bibliographical references.In South Africa assisted reproductive techniques (ART) are poorly covered by health insurances or government funding thereby often inflicting out-of-pocket payment (OPP) on patients.
Sherwood, Kerry Anne
core  

Access to assisted reproductive techniques through the Colombian health system [PDF]

, 2015
El objetivo de la investigación es determinar si el Estado colombiano está obligado a garantizar el acceso a técnicas de reproducción asistida a través de su Sistema de Salud a personas diagnosticadas con infertilidad.
Archila Julio, Jessica Johanna
core  

Physical & psychological changes associated with controlled Ovarian Hyperstimulation in women undergoing assisted reproductive techniques. (c1999)

, 1999
The clinical use of assisted reproductive techniques nowadays is intimately dependent on the use of controlled ovarian hyperstimulation. Ovarian hyperstimulation with Gonadotropin Releasing Hormone analogues (GnRHa) suppression of endogenous ...
Haddad, Rana
core   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Freezing the Biological Clock: A Viable Fertility Preservation Option for Young Singaporean Women?

, 2013
In March 2012, an article in The Straits Times entitled ‘Freezing eggs could reverse falling birth rate’ suggested that employing the latest oocyte cryopreservation techniques could both foster individual women’s reproductive autonomy and impact ...
Lee, Geok Ling, Blyth, E., Yee, Samantha, Blyth, Eric, Yee, S., Lee, G.L.   +5 more
core  

Legal problems arising from the application of assisted reproductive techniques

, 2022
Yıllar içerisinde infertilite sıklığındaki kademeli artış ile birlikte doğal yollardan çocuk sahibi olamayan kişilerin üreme hakkı, soybağını sürdürme hakkı gibi en temel kişilik haklarından mahrum kalması; toplumun ihtiyaçları ile örtüşen bir gelişim
Şen, Embiye
core  

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Ethical Considerations in Assisted Reproductive Techniques: A Scoping Review [PDF]

Journal of Mazandaran University of Medical Sciences
Background and purpose: Fertility has long been recognized as a fundamental aspect of human life because of its role in the continuation of generations and the fulfillment of parenthood.
Samira Malayen, Nasim Yousefi Ghand Ali, Zohreh Shahhosseini   +2 more
doaj