This real‐world study of ROS1+ NSCLC highlights fusion diversity, treatment outcomes with crizotinib and lorlatinib, and in vitro experiments with resistance mechanisms. G2032R drives strong resistance to ROS1‐targeted TKIs, especially lorlatinib. Fusion partner location does not affect overall survival to crizotinib or lorlatinib. Findings support the
Fenneke Zwierenga+8 more
wiley +1 more source
Ethical Imperatives in the Integration of Artificial Intelligence in Assisted Reproductive Technology. [PDF]
Nair N, Badge AK, Mishra V, Bankar NJ.
europepmc +1 more source
Should all infertile males undergo urologic evaluation before assisted reproductive technologies? Two cases of testicular cancer presenting with infertility [PDF]
Scott D. Simon+2 more
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We investigated whether hypomethylating agents (HMAs) used in myeloid malignancies induce somatic retrotransposition. Our findings indicate that HMA treatment increases L1‐encoded protein expression but does not lead to detectable de novo retrotransposition events in either patient samples or cell lines.
Šárka Pavlová+14 more
wiley +1 more source
A Qualitative Study of the Emotional and Decision-Making Experiences of Mothers Whose Daughter Undergoes Assisted Reproductive Technology with Donor Sperm. [PDF]
Wei Q+5 more
europepmc +1 more source
YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy+9 more
wiley +1 more source
Karyotypic analysis of 62,587 Han Chinese infertile couples undergoing assisted reproductive technology treatments: insights into chromosomal variations. [PDF]
Zhu S+7 more
europepmc +1 more source
Rights, technology, and services in reproductive health. A report from a meeting, 6-7 May 1999
Marion Carter, Charlie McGrory
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