Results 171 to 180 of about 5,493 (218)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

open access: yesMolecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu   +3 more
wiley   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant   +11 more
wiley   +1 more source
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Social Reproduction at Work, Social Reproduction as Work: A Feminist Political Economy Perspective

Journal of Labor and Society, 2021
Abstract Social reproduction has received considerable recent attention from academics and activists aiming to stimulate and advance transformative political change. Yet, an understanding of social reproduction as “work” has sometimes slipped away, leaving behind important anti-racist feminist insights.
Susan Braedley, Meg Luxton
openaire   +1 more source

Assessment of Reproductive Risk at Work

International Journal of Occupational and Environmental Health, 1996
The risk-assessment process involves hazard identification, dose&endash;response assessment, exposure assessment, and characterization of risk. Special competence and careful consideration are needed to assess effects on human reproduction. There is often a lack of scientific information concerning, e.g., toxic influences of chemical substances on ...
, Taskinen, , Ahlborg
openaire   +2 more sources

Reproduction and Work

Signs: Journal of Women in Culture and Society, 1975
The relationship between human health and the environment is generally acknowledged, even by those outside the professional medical and public-health arenas. Moreover, epidemiologists, whose responsibility is to identify possible cause and effect relationships in human disease, invariably include in their descriptions of a population under study its ...
openaire   +1 more source

Reproductive Health and Work: Different Experiences

Journal of Occupational & Environmental Medicine, 1998
Quebec and Denmark passed legislation in 1981 that aims to protect pregnant women and their unborn children from health hazards in the workplace. Finland passed similar legislation in 1991. While these measures have much in common, they are applied in very different ways.
R, Plante, R, Malenfant
openaire   +2 more sources

Improving work on herd reproduction

Животноводство России, 2021
Грамотно организованная работа по воспроизводству стада и выполнение рекомендаций специалистов позволяют наиболее полно реализовать генетический потенциал коров современных пород и тем самым повысить рентабельность молочных предприятий.
openaire   +1 more source

Working and reproductive years

2016
The longest stage of the life cycle comes between youth and old age. This stage combines productive development (labour market participation) and reproductive development (childbearing and the unpaid work of raising children and caring for older adults).
openaire   +1 more source

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