Results 31 to 40 of about 1,206,706 (321)

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Effects of the energy factor with regard to the US-China international relations within the Persian gulf region

Американська історія і політика, 2016
Referenced article is the overview of the important scientific problem – determination of the power industry influence on the US-China international relations within the Persian Gulf region. Persian Gulf region plays a really important role within the
Parkhomchuk Olena, Kononenko Mariya
doaj   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Chinese Guidelines for the Clinical Management of Obesity (2024 Edition)

Xiehe Yixue Zazhi
Obesity serves as a significant contributing factor to various chronic diseases, so standardized and systematic clinical management of obesity is crucial for enhancing overall health outcomes. Currently, there is a lack of comprehensive and authoritative
Department of Medical Administration, National Health Commission of the People's Republic of China
doaj   +1 more source

The activities of Russian public organizations in China in 1917 (on the example of the Russian colony in Manchuria and Xinjiang)

RUDN Journal of Russian History, 2019
The article analyzes activities of Russian public organizations in China in 1917 after the Russian February Revolution of 1917. Previously unstudied archival sources demonstrate that during that period, a large Russian diaspora formed in the Republic of ...
Elena N. Nazemtseva
doaj   +1 more source

Hong Kong – After the change of sovereignty [PDF]

, 1998
On 1 July 1997 the People’s Republic of China (PRC) resumed sovereignty over Hong Kong. Peter Willoughby (Consultant, Deacons Graham & James) summarises the impact on the laws of Hong Kong Special Administrative Region of the People’s Republic of China ...
Willoughby, Peter
core  

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Guidelines for the Diagnosis and Treatment of Primary Liver Cancer(2026 Edition)

Xiehe Yixue Zazhi
The Guidelines for the Diagnosis and Treatment of Primary Liver Cancer(2026 Edition) were officially finalized and released in April 2026, representing the most up-to-date national guidance for liver cancer management in China.
Department of Medical Administration, National Health Commission of the People's Republic of China
doaj   +1 more source

Comprehensive Characterization of 98 Chinese Cases of Genetic Creutzfeldt‐Jakob Disease With T188K Mutation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li, Dong‐Lin Liang, Li‐Ping Gao, Wei‐Wei Zhang, Wei Zhou, A. Ruhan, Bing Xu, Run‐Dong Cao, Kang Xiao, Cao Chen, Qi Shi, Xiao‐Ping Dong   +11 more
wiley   +1 more source

Clinical Practice Guideline for Primary Liver Cancer(2024 Edition)

Xiehe Yixue Zazhi
Primary liver cancer is one of the common malignant tumors in China. According to the cancer statistics report in China for the year 2022, the incidence and mortality rates of primary liver cancer in our country rank 5th and 2nd, with 367 700 new cases ...
Department of Medical Administration, National Health Commission of the People's Republic of China
doaj   +1 more source