Results 181 to 190 of about 669,285 (280)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

A Cross-Sectional Study Conducted in the USA Examining Associations Between Religious Engagement and Inpatient Hospital Experience and 30-Day Readmission. [PDF]

J Relig Health
Harmon BE, Lewis J, Ivery-Glover J, Baptist B, Daniel R, Warnock J, Smith S, Townsend S, Madubuonwu S.   +8 more
europepmc   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Preparation for Practice: Facilitating the Transition From Student to Physician Associate. [PDF]

Clin Teach
Lavallée JF, Horne R, Scotchburn H, Elliott K, Shepherd SC.   +4 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Construction of Paclitaxel-Loaded Poly (2-Hydroxyethyl Methacrylate)-g-Poly (Lactide)-1,2-Dipalmitoyl-Sn-Glycero-3-Phosphoethanolamine Copolymer Nanoparticle Delivery System and Evaluation of Its Anticancer Activity [Retraction]. [PDF]

Int J Nanomedicine
europepmc   +1 more source

Identification and management of the backup donor: recommendations from the World Marrow Donor Association. [PDF]

Bone Marrow Transplant
Greco-Stewart V, Manor S, Pollichieni S, Kathke A, Rall G, Evseeva I, Johnson P, Martfeld A, Schuit M, Tistl I.   +9 more
europepmc   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Enhancement of the capacity of a healthcare team through real-time information-sharing using a wireless intercom system: a prospective simulation study. [PDF]

BMJ Open
Sato H, Kuwabara D, Minoguchi K, Masubuchi T, Matsumoto M, Okuyama Y, Kawakami H, Abe T, Nakamura K, Goto T, Nakajima K.   +10 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source