Results 81 to 90 of about 669,285 (280)
Elk River Sediment Total Maximum Daily Load (TMDL) Summary and Implementation Framework and 2) Draft Basin Plan Amendment of Beneficial Uses [PDF]
that you initiate the process for identifying external scientific peer reviewers for two proposed actions related to the assessment and control of sediment discharges in the Elk River watershed.
Dr. Gerald Bowes +2 more
core
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Implementation Science, 2010 Background Randomised trials of knowledge translation strategies for professional behaviour change can provide robust estimates of effectiveness, but offer little insight into the causal mechanisms by which any change is produced.
Grimshaw Jeremy M +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
, 2013 The primordial perturbation is widely accepted to be generated through the vacuum fluctuation of the scalar field which drives inflation. It is, however, not completely clear what is the natural vacuum in the inflationary universe particularly in the ...
Tanaka, Takahiro, Urakawa, Yuko
core +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Assessing the Gravity Threshold under the ICC Statute. Criteria and Methods in the Light of the Gaza Freedom Flotilla Case [PDF]
, 2016 On 6 November 2015, the Appeals Chamber of the International Criminal Court (ICC), by 3 votes to 2, dismissed the Prosecutor’s appeal against Pre-Trial Chamber I’s ‘Decision on the request of the Union of the Comoros to review the Prosecutor’s decision ...
Cimiotta, Emanuele, Ragni, Chiara
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source