Results 131 to 140 of about 249,173 (312)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

A Social-Network-Based Crowd Selection Approach for Crowdsourcing Mobile Apps Requirements Engineering Tasks

Applied Sciences
Mobile apps have revolutionized almost every aspect of our daily lives, shaping the way we shop, learn and work. The transformative and unprecedented impact they have made on our lifestyle and the convenience they have offered have increased their ...
Ghadah Alamer, Sultan Alyahya, Hmood Al-Dossari   +2 more
doaj   +1 more source

QUALITATIVE COMPARISONS OF ELICITATION TECHNIQUES IN REQUIREMENT ENGINEERING [PDF]

, 2019
It is often emphasized that the quality of elicited requirement is mostly influenced by the elicitation techniques employed to gather software requirements.
Ogunbanwo, Afolakemi, Okokpujie, Kennedy O., Olamma , Iheanetu, Okesola, Olatunji J., Goddy-Worlu, Rowland   +4 more
core  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Engineering Functional Requirements

Requirements Engineering (RE) is a critical sub-field of engineering that deals with identifying, analysing, specifying, modelling, and validating the user needs and constraints for a system. This not only holds for Software Engineering (SE) but for engineering in general (e.g., for building bridges and other artefacts as well).
openaire   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Requirement Engineering in Component Selection

, 2010
M.E. (Software Engineering)In the COTS selection process, it is unavoidable to encounter mismatches between system requirements and COTS products’ capabilities.
Gupta, Rashmi
core  

Reverse Requirement Engineering

, 2020
Software ist mehr als nur Code. Laut Harlan Mills besteht Software aus verschiedenen Elementtypen wie Source-Code-Dateien, Maschinencode-Komponenten, Steuerungsprozeduren, Testfällen und Dokumenten. Die Dokumente, e.g.
Prentner, Wolfgang, Sneed, Harry M.
core  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Requirement analysis in medical phantom development: a survey tool approach with an illustrative example of a multimodal deformable pelvic phantom

Frontiers in Physics
IntroductionMedical phantoms play a crucial role in medical imaging and therapy. However, the successful development of these phantoms heavily relies on a comprehensive understanding of the requirements specific to each application.MethodsIn this paper ...
Marie Wegner, Marie Wegner, Jonte Schmiech, Eve Sobirey, Dieter Krause, Elisabetta Gargioni   +5 more
doaj   +1 more source