Results 51 to 60 of about 55,611 (297)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Towards a framework for improving requirement traceability

Ingeniería e Investigación, 2012
Work regarding requirement traceability focuses on programming aspects instead of identifying, analysing and modelling all traceable data in a software project.
Marco Antonio Toranzo Céspedes, Gilberto Cysneiros Filho, Yessica Gómez, Oscar Rodríguez Mendoza   +3 more
doaj  

Controlling Concurrent Change - A Multiview Approach Toward Updatable Vehicle Automation Systems [PDF]

, 2019
The development of SAE Level 3+ vehicles [{SAE}, 2014] poses new challenges not only for the functional development, but also for design and development processes. Such systems consist of a growing number of interconnected functional, as well as hardware
, Ernst, Rolf, Nolte, Marcus, Schlatow, Johannes   +3 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Problem-Frame-Oriented Requirements Traceability to Enhance Requirements Management

JOIV: International Journal on Informatics Visualization
Managing software requirements is a challenge in software development and maintenance. Requirements changes are inevitable, particularly in a rapid iterative development approach that leads to occasional changes in software requirements. Unable to manage
Xiao ShengWen, Sa'adah Hassan, Noraini Che Pa   +2 more
doaj   +1 more source

System engineering approach applied to Galileo system [PDF]

, 2010
Developing a localization system, with more precise performances than GPS that guarantees Europe autonomy is a complex challenge that ESA and a large number of European economical actors of space industry were decided to meet.
Bouchired, Steven, Lizy-Destrez, Stéphanie   +1 more
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Design of a conceptual reference model for implementation of traceability in a supply chain based upon structured modeling approach [PDF]

مدیریت صنعتی, 2011
Traceability is a basic requirement for the most of products from the viewpoint of governments and customers. It has base of quality systems and supports integration of supply chain information systems.
Jafar Razmi, Reza Tavakoli Moghadam, Fareiborz Jolai, Babak Yari   +3 more
doaj  

Artificial intelligence based muzzle recognition technology for individual identification of animals

Indian Journal of Animal Sciences, 2020
India is witnessing raising interest in animal identification and traceability in recent years. Identification and tagging of productive bovines across India with the internationally accepted 12 digit unique animal identification number using bar coded ...
P S GIRISH, SANTHOSH K, KARTIKEYA K, PRATHVI PALEKAR, HARIKRISHNA C H, SURESH RATHOD   +5 more
doaj   +1 more source

A flexible framework for requirement management (FFRM) from software architecture toward distributed agile framework

Open Computer Science, 2022
GSD is a Global software development environment where data are distributed to more than two sites. These sites may be located on national or continental borders.
Nadeem Rao, Amir Latif Rana M., Hussain Khalid, Jhanjhi N. Z., Humayun Mamoona   +4 more
doaj   +1 more source