Results 171 to 180 of about 26,437,347 (324)

Requirements analysis:

, 1998
Kimberley Ellis, Albert Jones, Tina Lee
openaire   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

An analysis of the job of farm manager in a corporate farming venture : a thesis presented in partial fulfilment of the requirements for the degree of Master of Agricultural Science in farm management at Massey University

, 1990
Bridget Wendy Hawkins
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Altered Regional Brain Activity Underlying the Higher Postoperative Analgesic Requirements in Abstinent Smokers: A Prospective Cohort Study. [PDF]

J Neurosci
Wei K, Tao K, Bi Y, Miao X, Xiao H, Zhang Y, Qiu H, Zhu J, Chen Q, Shen L, Xu H, Ma M, Hu L, Wang K, Lu Z.   +14 more
europepmc   +1 more source

Peer recognition of prodromal signs of psychosis : a signal detection analysis : a thesis presented in partial fulfilment of the requirements for the degree in Master of Arts in Psychology at Massey University, Palmerston North, New Zealand

, 2005
Robyn Joye Boyd
openalex   +1 more source

Analysis of beam position monitor requirements with Bayesian Gaussian regression [PDF]

, 2019
Yongjun Li, Yue Hao, Weixing Cheng, Robert Rainer   +3 more
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Scenario-based functional modularization framework for consumer electronics using MFD and AHP: A case study on audio products. [PDF]

PLoS One
Wu Z, Zhang J.
europepmc   +1 more source

DEVELOPMENT OF A SET OF CLOTHES FOR A COOK BASED ON THE ANALYSIS OF ERGONOMIC REQUIREMENTS [PDF]

К. Ж. Кучарбаева, А.А. Алимжанова, А.А. Алимжанова, Алматы технологиялық университеті, Алматы қ., Қазақстан Республикасы   +3 more
openalex   +1 more source