Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Research on the requirement characteristics and differentiated service design of home-based elderly care service in China using the candy model. [PDF]
Zhang D +5 more
europepmc +1 more source
Referrals for proliferative diabetic retinopathy from two UK diabetic retinopathy screening services: a 10-year analysis of visual outcomes, requirement for vitrectomy, and mortality [PDF]
Salman Naveed Sadiq +7 more
openalex +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Development of a Mobile Application for the Self-Management of Spinal Cord Injury Patients: Identification and Analysis of Key Requirements. [PDF]
Daeechini AH +5 more
europepmc +1 more source
A framework to support requirements analysis in engineering design
W. Brace, Vincent Cheutet
semanticscholar +1 more source
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Perioperative tranexamic acid in burn surgery: systematic review and meta-analysis of randomized controlled trials. [PDF]
Molinari ME +6 more
europepmc +1 more source

