Results 71 to 80 of about 29,604,152 (395)

Requirement Analysis for the DiSSCo Research Infrastructure [PDF]

Biodiversity Information Science and Standards, 2019
DiSSCo – the Distributed System of Scientific Collections – will mobilise, unify and deliver bio- and geo-diversity information at the scale, form and precision required by scientific communities, and thereby transform a fragmented landscape into a coherent and responsive research infrastructure.
Raes, Niels, van Egmond, Emily, Addink, Wouter, Hardisty, Alex   +3 more
openaire   +4 more sources

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

ANALYSIS OF THE NORMATIVE REQUIREMENTS FOR ENSURING

Transactions of the VŠB: Technical University of Ostrava, Safety Engineering Series, 2015
During the process of electrostatic powder coating in coating booths, there is a probability of the risk of explosion. Compliance with the normative requirements referred to in the legislation in force minimize the hazards associated with the risk of ...
Eva VELIČKOVÁ, Petr ŠTROCH, Richard VELIČKA   +2 more
doaj   +1 more source

Agree to Disagree: Security Requirements Are Different, But Mechanisms For Security Adaptation Are Not [PDF]

, 2018
We describe a dialogue between a proponent and an opponent of the proposition "security is not just another quality attribute in self-adaptive systems". The dialogue is structured in two steps.
Bennaceur, Amel, Tun, Thein
core   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Change Impact Analysis based on Formalization of Trace Relations for Requirements [PDF]

, 2008
Evolving customer needs is one of the driving factors in software development. There is a need to analyze the impact of requirement changes in order to determine possible conflicts and design alternatives influenced by these changes.
Berg, K.G. van den, Göknil, A., Kurtev, I.   +2 more
core   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum

FEBS Letters, EarlyView.
In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti, Sebastian Obermaier, Dirk J. Slotboom, Bert Poolman   +3 more
wiley   +1 more source

Sistematização de requisitos do usuário com o uso da Casa da Qualidade do QFD na etapa de concepção de unidades habitacionais de interesse social no âmbito do Programa Minha Casa, Minha Vida

Ambiente Construído
Resumo Este artigo propõe a estruturação e a organização dos requisitos do usuário como dados de entrada no processo de projeto de habitações de interesse social (HIS), de forma a propiciar o desenvolvimento de um produto com atributos que melhor atendam
Danilton Luis Lima Jesus de Aragão, Ercília Hitomi Hirota   +1 more
doaj   +1 more source

An airspace analysis according to area navigation requirements

Aviation, 2019
Aircraft navigation within controlled airspace is carried out using on-board positioning systems capable to determine the coordinates of aircraft location with the system performance that meet navigation specifications requirements.
Ivan Ostroumov, Volodymur Kharchenko, Nataliia Kuzmenko   +2 more
doaj   +1 more source