Results 171 to 180 of about 10,558 (216)

BAP31 Drives Cartilage Calcification through Disruption of Autophagosome–Lysosome Fusion in Osteoarthritis

Advanced Science, EarlyView.
Mechanical stress activates BAP31 in chondrocytes. BAP31 competes with ATG14 for binding to STX17, disrupting the STX17–ATG14 complex required for autophagosome–lysosome fusion. The resultant autophagic flux blockade drives the generation of autophagy‐derived exosomes, which mediate pathological cartilage calcification in OA. Chondrocyte‐targeted BAP31
Zhi‐hua Xu, Ruo‐xin Wang, Feng He, Qian Liu, Fu‐yin Li, Min Hui, Yu‐qian Shi, Yu Jiang, Qing‐hua Li, Jun‐wen Jing, Shi‐bin Yu, Li‐tian Ma, Qian‐nan Niu, Mian Zhang   +13 more
wiley   +1 more source

Bayesian prior elicitation on the efficacy of medical therapies in perianal fistulizing Crohn's disease. [PDF]

J Crohns Colitis
Noor NM, Zheng H, Cao Z, Caruso G, Voller C, Cooney R, Din S, Gordon H, Kok KB, Lindsay JO, Moran GW, Patel KV, Sebastian S, Raine T, Subramanian S, Hart AL, Robertson DS, Parkes M.   +17 more
europepmc   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

SCOPE: Stakeholder Consensus for Operational Pre-implementation Evidence A modified Nominal Group Technique for health innovation evaluation design

McMeekin P, Scott j.
europepmc   +1 more source

Design and Development of Rehabi, a mHealth Telerehabilitation Platform with Markerless Motion Analysis. [PDF]

Bioengineering (Basel)
González-Mendoza A, Aguilar-Sierra H, Zepeda-Mora R, Alessi-Montero A, Rodríguez-Reyes G, Carrera LN, Quiñones-Uriostegui I, Ayala-Cadena P, Gomez-Verdad A.   +8 more
europepmc   +1 more source

Synthetic Toll‐Like Receptors for Control of Innate Immunity With Far‐Red Light

Advanced Science, EarlyView.
Synthetic Toll‐like receptors (TLRs) are engineered by replacing their natural sensing regions with a far‐red‐light‐responsive module from a bacterial phytochrome. These synthetic receptors enable light‐controlled regulation of immune signaling in mammalian cells.
Anna V. Leopold, Vladislav V. Verkhusha
wiley   +1 more source

Studying dynamic sound source localization in a virtual maze with EEG and psychophysics. [PDF]

Front Neurosci
Strauss H, Grimm S, Feder S, Miksch J, Bendixen A.   +4 more
europepmc   +1 more source

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

SMART Planning of Early-Stage Health Economic Decision Models for Mechanism-Based Precision Treatments in Rare Cancers: An Application and Tool Update. [PDF]

Pharmacoeconomics
Abu-Zahra T, Grimm SE, Changoer P, Gerber NU, Mathes S, Netea-Maier RT, Joore M.   +6 more
europepmc   +1 more source