Results 231 to 240 of about 6,872,337 (300)

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Artificial intelligence needs a common ruler. [PDF]

Innovation (Camb)
Zhao Y, Song Z, Tan P, Xiong X, Fang X.
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Clinical pathway data engineering framework (CPDEF): a reproducible methodology for constructing machine learning-ready case-mix datasets from hospital information systems. [PDF]

MethodsX
Nugroho S, Ginardi RVH, Purnama IKE.
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

AI-assisted software development for brachytherapy seed inventory management. [PDF]

J Appl Clin Med Phys
Wang T, Beaudry J, Damato AL, Kollmeier M, Núñez DA.   +4 more
europepmc   +1 more source

Review of Multi-Scale Bridge Monitoring: An Information-Centric Framework Integrating Ground-Penetrating Radar, Distributed Optical-Fibre Sensing, and Satellite Remote Sensing for Bridge Digital Twins. [PDF]

Sensors (Basel)
Zou L, Li Y, Munisami K, Nico G, Alani AM.   +4 more
europepmc   +1 more source

Correction: Perivascular diffusion and white matter free water improve identification of cognitive impairment in cerebral small vessel disease. [PDF]

Front Neurol
Yang C, Cai S, Wang B, Zhou J, Wu D, Li M, Geng W, Wu L, Peng K, Yang Y, Gu W.   +10 more
europepmc   +1 more source

Biointegrative Design (BinD): An Interdisciplinary Paradigm for Sustainable Biohybrid Systems. [PDF]

Glob Chall
Miriyev A.
europepmc   +1 more source

Optimal parameters of roadway supports for water prevention based on the FFA algorithm. [PDF]

PLoS One
Xu C.
europepmc   +1 more source