Results 181 to 190 of about 1,067,278 (309)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

How can Iran's hospital accreditation standards align with ISQua? [PDF]

BMC Health Serv Res
Poursaki T, Shams L, Gharibi F.
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Development of the Vegan Protein Quality (VPQ) tool to derive smarter vegan meals with high protein quality. [PDF]

Sci Rep
Soh BXP, Vignes M, Smith NW, von Hurst PR, McNabb WC.   +4 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Compliance with Global Quality Requirements in Pakistan’s Export Sector

Lahore Journal of Economics
This paper describes the level of compliance with quality standards in relation to Pakistan’s top export product categories. With greater competition, innovations in technology, and stricter measures of quality being enforced, Pakistan needs to adopt a ...
Salman Ehsan, Ayesha Khanum
doaj  

Resuscitative thoracotomy in traumatic cardiac arrest : Multisociety consensus recommendations for settings with a low prevalence of penetrating injuries. [PDF]

Wien Klin Wochenschr
Dünser MW, Grassmann D, Hamp T, Krammel M, Eller P, Eisenburger P, Erblich R, Hallmann B, Halmich M, Hellwagner K, Herbich K, Herkner H, Knez I, Negrin LL, Rigaud M, Schlieber J, Schnaubelt S, Schreiber W, Stommel AM, Tomaselli F, Trimmel H, Veigl C, Voelckel W, Watzka S, Wiedemann D, Puchwein P.   +25 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

To combat poor quality research, eliminate publication requirements

EXCLI Journal : Experimental and Clinical Sciences
James Stacey Taylor
doaj   +1 more source

From Data Stewardship to Model Stewardship: Extending Governance Frameworks for AI Era Health Data Use. [PDF]

J Med Internet Res
Rozenblit L, Labkoff S, Safran C.
europepmc   +1 more source