Results 241 to 250 of about 9,353,128 (303)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Authority Without Infrastructure: A Researcher's Experience With Specimen Access Barriers in Sudden Unexpected Infant Death Research. [PDF]

Cureus
Goldman GS.
europepmc   +1 more source

Pandemic era expansion of state laws governing the professionalization of community health workers. [PDF]

Health Aff Sch
Weber-Fares R, Cheung T, Washburn DJ, Callaghan T, LaFleur M, Martinez D, Muthyala D, Warren K, Sage W, Schmit CD.   +9 more
europepmc   +1 more source

Strengthening the patient perspective in quality development: a mixed-methods observational study on suitability of the PROMIS GH-10 in Swiss inpatient rehabilitation. [PDF]

BMC Health Serv Res
Utsch M, Brupbacher G, Garuffi G, Scheel-Sailer A, Tobler S, Marquardt M.   +5 more
europepmc   +1 more source

Quality and Patient Safety Review Processes in Military Treatment Facilities and Operational Clinical Services.

Rand Health Q
Etchegaray JM, Chen PG, Hero JO, Matthews S, Yi S, Hepner KA.   +5 more
europepmc   +1 more source