Results 31 to 40 of about 1,680,422 (257)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

open access: yesFEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill   +6 more
wiley   +1 more source

"A Exemplaridade da Tradição", por Judith Martins-Costa — Editorial

open access: yes, 2009
Discurso de inauguração da Revista Res Severa Verum Gaudium – Centro Acadêmico André da Rocha – Faculdade de Direito – 9 de setembro de ...
Res Severa Verum Gaudium, Equipe Editorial
core   +2 more sources

Analysis of the “Adaptation strategy for sectors and areas vulnerable to climate change to 2020 with an outlook to 2030 (SPA 2020)” [PDF]

open access: yesArchives of Civil Engineering
Poland performs very badly in all kinds of rankings related to environmental protection and usually ranks last compared to other EU countries. Several programmes and strategies are currently being implemented to improve this situation. These include both
Janusz Sobieraj
doaj   +1 more source

Gradients of cortical hierarchy in Autism [PDF]

open access: yesResearch Ideas and Outcomes, 2017
Autism is a developmental condition associated with altered functional connectivity. We propose to re-frame the functional connectivity alterations in terms of gradients that capture the functional hierarchy of cortical processing from sensory to default-
Richard Bethlehem   +7 more
doaj   +2 more sources

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

open access: yesFEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson   +2 more
wiley   +1 more source

Die kontrollierte Impulsforscherin (Interview von Res Strehle)

open access: yes, 2015
Eine unbedachte Affekthandlung kann ein Leben ruinieren. Deshalb lohnt es sich, die Impulskontrolle besser zu verstehen. Führend dabei ist Daria Knoch an der Uni Bern. Interview von Res Strehle, ehemaliger Chefredaktor des Tages-Anzeigers, mit Frau Prof.
Strehle, Res, Knoch, Daria
core   +1 more source

The state of the market of hydrogen raw materials in Russia and the world

open access: yesУправление
The study analyses the current state and prospects of hydrogen energy and its impact on macro- and microeconomic indicators both development in Russia and in the world as a whole.
V. Yu. Linnik   +2 more
doaj   +1 more source

OASIcs, Volume 108, NG-RES 2023, Complete Volume

open access: yes, 2023
OASIcs, Volume 108, NG-RES 2023, Complete ...
Cattaneo, Daniele, Terraneo, Federico
core   +1 more source

Heterotropic regulation and negative homotropic cooperativity

open access: yesFEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea   +5 more
wiley   +1 more source

The impact of recession on public attitudes towards energy and the environment

open access: yesInternational Journal of Sustainable Energy, 2017
This article presents a panhellenic social survey regarding environmental subjects in Greece. It is a well-known fact that Greece is suffering from an economic crisis among other European Union countries.
Panos Kosmopoulos   +4 more
doaj   +1 more source

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