Results 61 to 70 of about 97,360 (268)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Emergency services to the rescue, or not, again [PDF]

open access: yes, 2008
Re-considers whether a duty of professional rescue by the emergency services might be recognised. The paper argues that the rejection of liability by the House of Lords in the cases of Van Colle v CC of Hertfordshire and Smith v CC of Sussex Police in ...
Williams, K.
core  

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

La deshabituación tabaquica con técnicas de medicina tradicional y natural Smoking cessation with natural and tradictional technniques

open access: yesRevista Habanera de Ciencias Médicas, 2009
Se realizó un estudio longitudinal en la Clínica de Medicina Tradicional Natural Boyeros, en los años 2004 al 2006, con los objetivos de evaluar la efectividad de las técnicas auriculoterapia, terapia floral y la terapia grupal en la deshabituación ...
María Asunción Tosar Pérez   +3 more
doaj  

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Efectividad de la terapia floral de Bach en pacientes con hipertensión arterial

open access: yesMedisan
Se realizó un estudio descriptivo, longitudinal y prospectivo de 40 pacientes con hipertensión arterial descontrolada, atendidos en el cuerpo de guardia del Hospital General Docente Dr.
Gricel Benítez Rodríguez   +1 more
doaj  

Volume 2 - April 18, 1991 [PDF]

open access: yes, 1991
What on Earth was a short-run student publication by the Providence College Environmental and Wildlife Club. (Volume 2 - April 18, 1991 - 8 pages total.

core   +1 more source

American Medicine and the Politics of Race [PDF]

open access: yes, 2005
Straw men play a major role in the debate over racial disparity in American medicine. Most have been deployed by the disparities-denying right, but progressives intent on “outing” racism have sent forth their share.
Bloche, Maxwell Gregg
core   +2 more sources

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