Results 161 to 170 of about 66,532,896 (251)

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Bibliometric Insights in Advances of Chordoma: Global Trends and Research Development in the Last Decade. [PDF]

Orthop Surg, 2023
Xiao Y, Yu W, Zheng J, Cheng L, Ding X, Qiao L, Wu X, Ma J.   +7 more
europepmc   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

A Framework for Assessing the Opportunity for Advanced Research, Development, and Regulatory Approval of Medical Countermeasures: A Component of BARDA's Emerging Infectious Diseases Strategy. [PDF]

J Infect Dis
White RC, Lewis RG, Little JD, Fredericksen BL, Sabourin CL, Lane MC, Loelius SG, Hofmeyer KA, Steele M, Tong X, Johnson RA.   +10 more
europepmc   +1 more source

The research development of STAT3 in hepatic ischemia-reperfusion injury. [PDF]

Front Immunol, 2023
Yang H, Zhang P, Wang Q, Cheng K, Zhao Y.   +4 more
europepmc   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Patient and Stakeholder Collaborative Research: Development of a Community Advisory Board for Nephrology and Transplantation Studies. [PDF]

Kidney Med
Ghildayal N, Scherer J, Nalatwad A, Mittleman I, Jones J, Keefer V, Nadkarni S, Palmer M, Levan ML, Hall R, Segev DL, McAdams-DeMarco M.   +11 more
europepmc   +1 more source

Liquid metal cooled fast reactor thermal hydraulic research development: A review. [PDF]

Heliyon, 2023
Agbevanu KT, Debrah SK, Arthur EM, Shitsi E.   +3 more
europepmc   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Editorial: Advances in bacteriophage research & development with therapeutic applications. [PDF]

Front Cell Infect Microbiol
Gonzalez Moreno M, Alt S, Mercer D.
europepmc   +1 more source