Results 301 to 310 of about 65,650,609 (376)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

From chaos to symbiosis: exploring adaptive co-evolution strategies for generative AI and research integrity systems. [PDF]

BMC Med Ethics
Miao W, Zang H, Liu Q, Zheng T, Zhou Y, Liu C, Yang N, Zhang H, Zhang Y, Zhang Y, Li S, Zhang S, Zhang H.   +12 more
europepmc   +1 more source

A conversation with Keith McCrae, MD, staff and professor of molecular medicine, Cleveland Clinic

Journal of Clinical and Translational Science
Clinical Research Forum
doaj   +1 more source

GUUAM: view from Ukraine [PDF]

, 2001
Research, Update
core  

Single‐cell transcriptomics redefines focal neuroendocrine differentiation as a distinct prostate cancer pathology

Molecular Oncology, EarlyView.
Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban, Shivakumar Keerthikumar, Ashlee Clark, Hong Wang, Belinda Phipson, Andrew Bakshi, Andrew Ryan, Heather Thorne, Renea A. Taylor, Mitchell G. Lawrence, Gail P. Risbridger, Roxanne Toivanen, David L. Goode   +12 more
wiley   +1 more source

Population data on Finland 1900-1983

Finnish Yearbook of Population Research, 1984
Population Research Institute
doaj  

Draft 2000 budget rejected in the first reading [PDF]

, 1999
Research, Update
core  

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

A global analysis of the rise, reign, and retreat of topics in research toward sustainable platform chemicals.

Green Chem
Tautorat P, Tremolada B, Martín AJ, Santos LF, Guillén-Gosálbez G, Pérez-Ramírez J, Steffen B.   +6 more
europepmc   +1 more source

Historical Nonsuicidal Self-Injury and Current Coping Strategies: The Role of Emotion Regulation. [PDF]

Personal Ment Health
Bradley H, Orchard F, Matcham F.
europepmc   +1 more source