Results 61 to 70 of about 33,710,537 (347)
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
Boletín Científico Sapiens Research, 2015 Objetivos: Publicar el listado de universidades con membresía de Sapiens Research Group; el noveno reporte de las mejores instituciones de educación superior colombianas según indicadores de investigación; un análisis de las mejores 10 IES; la dinámica ...
Sapiens Research Group
doaj
School Science and Mathematics, 1916 Nearly all the results of modern research are published in short technical articles, of interest only to those who are working in the same or allied fields. Occasionally, some man, well versed in the details of subject, will summarize the work of a given field in a book.
openaire +3 more sources
FEBS Letters, EarlyView.Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli +10 more
wiley +1 more source
Land Magnetic Observations, 1911-1913 and Reports on Special Researches . By L. A. Bauer and J. A. Fleming. Washington, D. C., 1915. Publication No. 175, Vol. 2, of the Carnegie Institution of Washington. 4to. Pp. v + 278. 13 plates, 9 text-figures. [PDF]
, 1916 W. G. Cady
openalex +1 more source
Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source
FEBS Letters, EarlyView.This work presents the characterization of MvoDUF2193, a Methanococcus voltae (Mvo) protein from the domain of unknown function (DUF) 2193 family. We demonstrate that MvoDUF2193 binds a single [4Fe–4S] cluster per subunit and that cluster occupancy regulates the transition from an apo tetramer to a [4Fe–4S] monomeric form. This structural transition is
Emily M. Dieter +8 more
wiley +1 more source