Results 191 to 200 of about 74,584,174 (296)

Qili Qiangxin capsule as adjunctive therapy for heart failure after acute myocardial infarction: a GRADE-assessed systematic review and meta-analysis of randomised controlled trials. [PDF]

Front Pharmacol
Yu JH, Yu HY, Zhang JC, Chen ZY, Wang C, Wu YQ, Wang YF, Robinson N, Liu JP, Li YL, Liang SB.   +10 more
europepmc   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Updates on the Translational Value of Idiopathic Pulmonary Fibrosis Models Across Species: Deeper Insights Through Comparative Pathology. [PDF]

Biomolecules
Gargiulo S, Gramanzini M, Bonente D, Barone V.   +3 more
europepmc   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Early mRNA expression of pro-inflammatory cytokines and ADAMTS-5 in an acute ischemia/reperfusion-induced pressure ulcer model, a pilot exploratory animal study. [PDF]

Turk J Phys Med Rehabil
Sağlam M, Yanık B, Erdoğan E, Yaşar ZS, Cemeroğlu Ö, Bakan B, Çakırbay H.   +6 more
europepmc   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Errate: Nasal Mucociliary Clearance and Its Relationship With Disease Severity in Patients With Multiple Sclerosis. [PDF]

Med Sci Monit
Baydar C, Yalınkılıç A, Çetin YS.
europepmc   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Modulation of the Liver-Brain Axis by Ondansetron in Thio-Acetamide-Induced Acute Hepatic Encephalopathy. [PDF]

Int J Mol Sci
Sari FM, Bilgin Y, Cicek B, Kurt E, Ozkaraca M, Gungor A, Kurt N, Bilgin AO.   +7 more
europepmc   +1 more source