FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
From past to future: bibliometric perspective of international research activity on lateral epicondylitis. [PDF]
Front SurgShu B, Zhang S, Gao J, Wang L, Wang X.
europepmc +1 more source
Relationship Between Research Culture and Research Activity of Medical Doctors: A Survey and Audit. [PDF]
J Multidiscip Healthc, 2021 Brandenburg C +6 more
europepmc +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Health Emergency Research Preparedness: An Analysis of National Pre‑COVID Research Activity and COVID Research Output. [PDF]
Ann Glob HealthKilmarx PH, Kyere S.
europepmc +1 more source
Expanding the Assessment of Research Activity. [PDF]
Clin Neuroradiol, 2020 Solymosi L.
europepmc +1 more source
Conflict of interest declarations in published healthcare reports and the need for supportive legislative frameworks: focus on hospital pharmacists' research activity worldwide. [PDF]
Eur J Hosp Pharm, 2023 Zovi A, Santoleri F, Lasala R.
europepmc +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Global research activity on mathematical modeling of transmission and control of 23 selected infectious disease outbreak. [PDF]
Global Health, 2022 Sweileh WM.
europepmc +1 more source