Results 241 to 250 of about 59,223,825 (281)
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
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Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
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Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
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American Journal of Psychiatry, 1972
The personality structure of activists was compared with those of activist-sympathizers and conservatives on a university campus. The activists were most clearly distinguished from the other two groups in their manifestation of unconscious ambivalence toward their fathers and in their conflict over middleclass values.
R S, Berns, D E, Bugental, G P, Berns
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The personality structure of activists was compared with those of activist-sympathizers and conservatives on a university campus. The activists were most clearly distinguished from the other two groups in their manifestation of unconscious ambivalence toward their fathers and in their conflict over middleclass values.
R S, Berns, D E, Bugental, G P, Berns
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Journal of Intellectual & Developmental Disability, 2008
The active support model (AS) was developed and refined by researchers and practitioners in the UK during the 1980s and 1990s in the context of community group homes for people with intellectual di...
Roger J, Stancliffe +2 more
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The active support model (AS) was developed and refined by researchers and practitioners in the UK during the 1980s and 1990s in the context of community group homes for people with intellectual di...
Roger J, Stancliffe +2 more
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Research Activities Of Clinical Nurse Researchers
Nursing Research, 1987A nationwide telephone survey was carried out on 34 nurses employed as researchers in clinical settings (CNRs). CNRs reported current involvement in over 200 projects with a range from 1 to 29 projects. Projects were categorized into the following types: clinical practice, nursing administration, evaluation, education, or methodology. Almost half (47%)
K A, Knafl, M E, Bevis, K T, Kirchhoff
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Textile Research, 1941
promptu poll of the group, which is a representative cross-section of 2,300 industrial research laboratories in the United States, disclosed that in 1942 all plan either to maintain or to increase their present rate of their research activities.
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promptu poll of the group, which is a representative cross-section of 2,300 industrial research laboratories in the United States, disclosed that in 1942 all plan either to maintain or to increase their present rate of their research activities.
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Written Communication, 2005
This article traces the historical and conceptual development of what is known as activity theory, from Vygotsky and Luria, to A. N. Leont’ev, to Engeström, in order to illustrate what I see as two problems with the activity theoretic approach, especially as manifest in the work of Leont’ev and Engeström: what I call the boundary and/or focus problem ...
Stephen P. Witte, Christina Haas
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This article traces the historical and conceptual development of what is known as activity theory, from Vygotsky and Luria, to A. N. Leont’ev, to Engeström, in order to illustrate what I see as two problems with the activity theoretic approach, especially as manifest in the work of Leont’ev and Engeström: what I call the boundary and/or focus problem ...
Stephen P. Witte, Christina Haas
openaire +1 more source