Results 201 to 210 of about 14,722,971 (292)

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Operationalizing the One Health approach at the intersection of research and development: a study protocol for the ELUZO project in Senegal and Burkina Faso. [PDF]

Glob Health Action
Hubert M, Martin M, Carabin H, Parmley J, Gilbert-Vanasse M, Kafando A, Seck R, Murphy HM, Ba MF, Ilboudo AK, Alambédji RB, Batal M, Bicaba A, Bicaba FLB, Blanchet R, Castonguay FM, Diallo AI, Diop F, Druetz T, Jobin-Gélinas M, Kagambéga A, Kazienga A, Korogo S, Mac-Seing M, Primeau MD, Ratelle M, Sougou NM, Tine PC, Tarnagda Z, Faye A, Bouchard M.   +30 more
europepmc   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Advancing health equity in cancer care through collaborative research agenda development: a provincial workshop guided by patient-oriented research in Alberta, Canada. [PDF]

Front Oncol
Pujadas Botey A, Judge H, Robson PJ, Santos Salas A.   +3 more
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

A Mobile Application for Fall Prevention Among Older Adults in Rural Thailand: A Research and Development Approach. [PDF]

Health Promot Perspect
Yokphonchanachai C, Paengprakhon Y, Duangsri J, Chada W, Raksilp M, Songserm N.   +5 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Trends in funding for coronavirus vaccine research and development: implications for preparedness against future coronavirus threats. [PDF]

NPJ Vaccines
Fleming D, Smith E, Ostrowsky J, Ulrich A, Leighton T, Vestin N, Mehr AJ, Furst R, Norton A, Lackritz E.   +9 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Status, challenges, and prospects of artificial intelligence application in gout diagnosis and treatment, drug research and development, and disease monitoring. [PDF]

Front Med (Lausanne)
Ma J, Zhao J, Liu X, Yan J, Hou Y, Li C, Man D, Wang C, Li H, Wang Y.   +9 more
europepmc   +1 more source