Results 231 to 240 of about 14,722,971 (292)

How to promote universities' research and development into green agricultural products - A tripartite evolutionary game analysis. [PDF]

PLoS One
Xiong L, Chang L, Luo Y, Wu H, Wang Y, Jin H.   +5 more
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Evaluation of scientific outcomes of TDR-supported clinical research and development fellows in low- and middle-income countries: a bibliometric analysis. [PDF]

Infect Dis Poverty
Vahedi M, Dahal P, Jaberi E, Assefa DG, Maula W, Casamitjana N, Launois P.   +6 more
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

A rapid tool for understanding how knowledge users engage with research findings in research-for-development contexts. [PDF]

Health Res Policy Syst
Lam S, Hoffmann V, Otoigo L, Nguyen-Viet H.   +3 more
europepmc   +1 more source

Standardization of <i>in-vitro</i> evaluation of extracorporeal life support (ECLS) devices for research and development. [PDF]

Perfusion
Arens J, Belliato M, Broman LM, Clauser JC, Donker DW, Lorusso R, Malfertheiner M, Rajsic S, Swol J, Vercaemst L, Prahl Wittberg L.   +10 more
europepmc   +1 more source

Research and Development of Cement-Based Dynamic Water Grouting Material for the CSM Construction Method. [PDF]

Materials (Basel)
Yang Z, Zhang F, Chang Y, Yang X, Li J, Feng Q, Wang H, Tong H.   +7 more
europepmc   +1 more source

Research and development of novel embolization materials and study on their feasibility of preventing T2EL after EVAR abdominal aortic aneurysm. [PDF]

Front Cardiovasc Med
Erdemutu E, Huang B, Hu L, Yin S, Lan Y, Zhou C, Dai X.   +6 more
europepmc   +1 more source

Retrieva’s Research and Development

Journal of Natural Language Processing
openaire   +2 more sources

The collaborations among healthcare systems, research institutions, and industry on artificial intelligence research and development. [PDF]

Front Artif Intell
Ye J, Ma M, Abuhashish M.
europepmc   +1 more source