Results 191 to 200 of about 7,390,753 (310)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

A scoping review on what constitutes a good research culture. [PDF]

F1000Res
Blatch-Jones AJ, Lakin K, Thomas S.
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Embedding research into the organisational structure of smaller rural hospitals: building research culture and capacity and understanding perceived rural health workforce benefit. [PDF]

BMC Health Serv Res
Alston L, Pu D, Wood S, Field M, Beks H, King OA, Wheaton N, Huggins CE, Shee AW, Namara KM, Versace VL.   +10 more
europepmc   +1 more source

Promoting Research Culture at Indus Health Network. [PDF]

Pak J Med Sci, 2020
Jawaid SA.
europepmc   +1 more source

"Global mediation: Performing Shakespeare in the age of networked and digital cultures," The Arden Research Handbook of Shakespeare and Contemporary Performance, ed. Peter Kirwan and Kathryn Prince (London: Bloomsbury, 2021), pp. 132-150

, 2021
Alexa Alice Joubin
openalex   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Nurturing a positive research culture within your laboratory. [PDF]

Wellcome Open Res
Liston A, Fitzgerald DC.
europepmc   +1 more source

Research on the Marketing Strategy of Music Culture Industry Driven by New Media Platform [PDF]

Z A Li
openalex   +1 more source

A Summary of Research on the Integration of Chinese Traditional Etiquette Culture into Higher Vocational Education

, 2022
Qinqin Sui
openalex   +1 more source