Results 161 to 170 of about 9,082,977 (268)

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Ten simple rules for effective research data management. [PDF]

PLoS Comput Biol
Hassenstein MJ, Jung K.
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

RDMkit: A research data management toolkit for life sciences. [PDF]

Patterns (N Y)
Alper P, D'Anna F, Droesbeke B, Andrabi M, Andrade Buono R, Bianchini F, Bösl K, Chandramouliswaran I, Cook M, Faria D, Fatima N, Hooft R, Jareborg N, Jetten M, Pilvar D, Poires-Oliveira G, Popleteeva M, Portell-Silva L, Slifka J, Suchánek M, van Gelder C, Welter D, Wittig U, Coppens F, Goble C.   +24 more
europepmc   +1 more source

Research data management in health and biomedical citizen science: practices and prospects. [PDF]

JAMIA Open, 2020
Borda A, Gray K, Fu Y.
europepmc   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Evolve with your research: stepwise system evolution from document-driven to fact-centric research data management in materials science. [PDF]

J Cheminform
Dudarev V, Ludwig A.
europepmc   +1 more source

Research Data Management in Natural History [PDF]

, 2018
Donaldson, Mary
core  

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

Rooting for data: A FAIR research data management and data analysis environment for the PlantMicrobe research collaboration. [PDF]

PLoS Pathog
Dröst F, Eberhardt U, Wellmann A, Saker H, Pirkl S, Krinninger M, Klingl A, Kemen E, Kamal N, Hachinger S, Krüger J.   +10 more
europepmc   +1 more source