Results 51 to 60 of about 38,763 (257)
False economy? The costs of contracting and workforce insecurity in the voluntary sector [PDF]
, 2007 The purpose of this project has been to gain insights into the direct and indirect implications of the insecure funding regime faced by the social care sector, with a particular focus on those relating to employment and service quality.
Cunningham, Ian, James, Philip
core
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
International Journal of Digital CurationThe complexity around data management decisions is a tangible burden to researchers and can be a significant barrier to engaging with Open Science principles. Researchers often face a multitude of choices regarding storage solutions, sharing technologies, security, and legal and ethical concerns, each with its own set of implications for their work ...
Marcel Ras, Elisa Rodenburg
openaire +1 more source
Automated progress identification and feedback in large experimental laboratories [PDF]
, 2001 In this work we describe a novel web-based system whose aim is to enhance the learning environment within experimental laboratories, and report on its deployment in undergraduate computer architecture modules.
Joy, Mike +2 more
core
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
, 2019 The project Research Data Management Organiser (RDMO)1 develops a tool to support the planning, implementation and organisation of research data management. The multilingual open source tool can be installed locally and adapted to institutional or discipline-specific needs with regards to contents. It provides interfaces to institutional authentication
Engelhardt, Claudia +4 more
openaire +1 more source
, 2020 Does your organisation want to develop requirements for data management plans (DMPs) or update existing ones? Take a look at our latest publication to find out how to do so in three steps. In January 2019, Science Europe released its ‘Practical Guide to the International Alignment of Research Data Management’ which has been taken up by numerous Science
openaire +1 more source
The safety case and the lessons learned for the reliability and maintainability case [PDF]
, 2005 This paper examine the safety case and the lessons learned for the reliability and maintainability ...
Bedford, T.J. +2 more
core
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Challenges in interface and interaction design for context-aware augmented memory systems [PDF]
, 2007 The human long-term memory is astonishingly powerful but fallible at the same time. This makes it very easy to forget information one is sure one actually knows. We propose context-aware augmented memory systems as a solution to this problem.
Hinze, Annika, Schweer, Andrea
core +2 more sources