Results 241 to 250 of about 77,036,499 (314)

Correction: Informing research design through patient and public involvement; patients and carers with lived experience post-hospital discharge and potential roles for general practice pharmacists. [PDF]

BMC Res Notes
Yahya F, Bartlett S, Paudyal V, Hadi MA, Nazar H, Maidment I.   +5 more
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Development of a Mobile-Based Personal Health Record for Pediatric Attention-Deficit/Hyperactivity Disorder Management: Protocol for a Study Based on Action Research Design. [PDF]

JMIR Res Protoc
Santoso DB, Kristanti MS, Nurputra DK, Sutomo R.   +3 more
europepmc   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Including Prisoners in Research Design: Codevelopment of a Practical Guidance Toolkit to Support Intervention Delivery to Address the Physical and Mental Health of Older Prisoners (PAMHOP) Study. [PDF]

Health Expect
Perry AE, Moe-Byrne T, Schofield J, Ashton L, Siqueria N, Knowles S, Churchill PR, Colman T, Parrott S, Williamson K.   +9 more
europepmc   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Informing research design through patient and public involvement; patients and carers with lived experience post-hospital discharge and potential roles for general practice pharmacists. [PDF]

BMC Res Notes
Yahya F, Bartlett S, Paudyal V, Hadi MA, Nazar H, Maidment I.   +5 more
europepmc   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Exploring Health Literacy Among Parents of Children Who Attended the Pediatric Rehabilitation Clinics in Qatar: A Convergent Parallel Research Design. [PDF]

SAGE Open Nurs
Johnson J, Khraim F, Wolsey C, Elshatarat RA, Thornton L, Schnurman D, AlDalaykeh M, Al-Farsi A.   +7 more
europepmc   +1 more source

Research design justification for different regional blocks following modified radical mastectomy. [PDF]

Indian J Anaesth
Mohammed S, Bhatia P, Chhabra S, Sharma L, Kumar M, Sethi P.   +5 more
europepmc   +1 more source