Results 41 to 50 of about 654,709 (293)
Application of Failure Modes and Effects Analysis in the Engineering Design Process [PDF]
arXiv, 2021 Failure modes and effects analysis (FMEA) is one of the most practical design tools implemented in the product design to analyze the possible failures and to improve the design. The use of FMEA is diversified, and different approaches are proposed by various organizations and researchers from one application to another.
arxiv
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Ecology and Society, 2019 Ecosystem services inherently involve people, whose values help define the benefits of nature's services. It is thus important for researchers to involve stakeholders in ecosystem services research.
Heather A. Schoonover +7 more
doaj +1 more source
Journal of Investigative Surgery, 2012 The development of a good research design permits us to obtain the best research data possible. From the experimental question to the research hypothesis and data collection variables, we can begin to consider the optimal research design. Details pertaining to the selection of the research design are considered within and very much in relation with the
openaire +2 more sources
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Future Internet, 2021 Blockchain is predicted to disrupt industries, economies, and societies. The properties of distributed ledgers allow the creation of immutable data structures that facilitate shared access in real time and enable a plethora of innovative applications ...
Horst Treiblmaier
doaj +1 more source
Diphthamide synthesis is linked to the eEF2‐client chaperone machinery
FEBS Letters, EarlyView.The diphthamide modification of eukaryotic translation elongation factor 2 (eEF2) is important for accurate protein synthesis. We addressed the potential coordination of de novo eEF2 synthesis with simultaneous or subsequent diphthamide modification. Our work reveals that the co‐chaperones Hgh1 and Cpr7, which are known to support folding of nascent ...
Lars Kaduhr +4 more
wiley +1 more source
Design Science Research Process: A Model for Producing and Presenting Information Systems Research [PDF]
in the Proceedings of the First International Conference on Design
Science Research in Information Systems and Technology, pp. 83-16. 2006,
Claremont, California, USA, 2020 The authors design and demonstrate a process for carrying out design science (DS) research in information systems and demonstrate use of the process to conduct research in two case studies. Several IS researchers have pioneered the acceptance of DS research in IS, but in the last 15 years little DS research has been done within the discipline. The lack
arxiv
Reasons, Challenges and Some Tools for Doing Reproducible Research in Transportation Research [PDF]
arXiv, 2021 This paper introduces reproducible research, and explains its importance, benefits and challenges. Some important tools for conducting reproducible research in Transportation Research are also introduced. Moreover, the source code for generating this paper has been designed in a way so that it can be used as a template for researchers to write their ...
arxiv
Deep Generative Design: Integration of Topology Optimization and Generative Models [PDF]
Journal of Mechanical Design, 141(11), 111405, 2019 Deep learning has recently been applied to various research areas of design optimization. This study presents the need and effectiveness of adopting deep learning for generative design (or design exploration) research area. This work proposes an artificial intelligent (AI)-based design automation framework that is capable of generating numerous design ...
arxiv +1 more source