Results 121 to 130 of about 2,205,527 (302)

Irritability through Research Domain Criteria: An opportunity for transdiagnostic conceptualisation

, 2020
Irritability is a transdiagnostic phenomenon that, despite its ubiquity and significant impact, is poorly conceptualised, defined and measured. As it lacks specificity, efforts to examine irritability in adults by using a diagnostic category perspective ...
Boyce, P, Malhi, GS, Bell, E, Porter, RJ, Bryant, RA   +4 more
core   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Distinct Neural Signatures Detected for ADHD Subtypes After Controlling for Micro-Movements in Resting State Functional Connectivity MRI Data

Frontiers in Systems Neuroscience, 2013
In recent years, there has been growing enthusiasm that functional MRI could achieve clinical utility for a broad range of neuropsychiatric disorders. However, several barriers remain.
Damien eFair, Joel T Nigg, Swathi eIyer, Deepti eBathula, Kathryn L Mills, Nico UF Dosenbach, Bradley L Schlaggar, Maarten eMennes, David eGutman, Saroja eBangaru, Jan K Buitelaar, Daniel P Dickstein, Adriana eDi Martino, David N Kennedy, Clare eKelly, Beatriz eLuna, Julie B Schweitzer, Katerina eVelanova, Yu-Feng eWang, Yu-Feng eWang, Stewart H Mostofsky, Stewart H Mostofsky, Francisco Xavier Castellanos, Francisco Xavier Castellanos, Michael P Milham, Michael P Milham   +25 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Empirically Supported Psychological Treatments and the Research Domain Criteria (RDoC)

, 2017
Background: The Research Domain Criteria (RDoC) has been developed as an alternative approach to studying psychiatric disorders. The RDoC constructs and units of analysis, from genes up through paradigms, are intended to describe a hierarchy of priority ...
Tolin, David, McKay, Dean
core  

Operationalizing NIMH Research Domain Criteria (RDoC) in naturalistic clinical settings [PDF]

, 2016
Recently, the National Institute of Mental Health (NIMH) introduced the Research Domain Criteria (RDoC) initiative to address two major challenges facing the field of psychiatry: (1) the lack of new effective personalized treatments for psychiatric ...
Fonagy, P, Oldham, J, Madan, A, Allen, J, Matthew, S, Fowler, C, Salas, R, Sharp, C, Kosten, T, Frueh, BC, Nielsen, D   +10 more
core  

A synthesis of evidence on inhibitory control and auditory hallucinations based on the Research Domain Criteria (RDoC) framework.

Frontiers in Human Neuroscience, 2014
The National Institute of Mental Health initiative called the Research Domain Criteria (RDoC) project aims to provide a new approach to understanding mental illness grounded in the fundamental domains of human behaviour and psychological functioning.
Johanna C. Badcock, Johanna C. Badcock, Kenneth eHugdahl   +2 more
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Cooking for disability: a pilot study on nutritional interventions for mental health support in adults with autism spectrum disorder

Frontiers in Psychiatry
BackgroundAutism Spectrum Disorder (ASD) is a complex neurodevelopmental condition often accompanied by chronic inflammation and metabolic dysfunction, which are increasingly recognized as key contributors to symptom severity and behavioral challenges ...
Johanna Maria Catharina Blom, Ciro Ruggerini, Franco Caroli, Carla Ferreri, Annalisa Masi, Veronica Rivi, Pierfrancesco Sarti, Mauro Rebecchi, Chiara Arletti   +8 more
doaj   +1 more source