Results 201 to 210 of about 10,894,164 (293)

The role of mentors in addressing issues of work-life integration in an academic research environment. [PDF]

J Clin Transl Sci, 2019
Durbin DR, House SC, Meagher EA, Rogers JG.   +3 more
europepmc   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Open is not enough. Let’s take the next step: An integrated, community-driven computing platform for neuroscience

Frontiers in Neuroinformatics, 2012
Yaroslav O. Halchenko, Yaroslav O. Halchenko, Yaroslav O. Halchenko, Michael eHanke, Michael eHanke, Michael eHanke   +5 more
doaj   +1 more source

Understanding who is and isn’t involved and engaged in health research: Feasibility of capturing and analysing demographic data related to patient and public involvement and engagement within a clinical translational research environment

, 2022
Keane A, Islam S, Parsons S, Verma A, Farragher T, Forde D, Holmes L, Cresswell K, Williams S, Arru P, Howlett E, Turner-Uaandja H, MacGregor I, Grey T, Arain Z, Scahill M, Starling B.   +16 more
europepmc   +1 more source

OPTIMAL ENTERPRISE RESULTS IN THE CLINICAL RESEARCH ENVIRONMENT. [PDF]

Proc Winter Simul Conf, 2018
Rodriguez AR.
europepmc   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

West-Life: A Virtual Research Environment for structural biology. [PDF]

J Struct Biol X, 2019
Morris C, Andreetto P, Banci L, Bonvin AMJJ, Chojnowski G, Cano LD, Carazo JM, Conesa P, Daenke S, Damaskos G, Giachetti A, Haley NEC, Hekkelman ML, Heuser P, Joosten RP, Kouřil D, Křenek A, Kulhánek T, Lamzin VS, Nadzirin N, Perrakis A, Rosato A, Sanderson F, Segura J, Schaarschmidt J, Sobolev E, Traldi S, Trellet ME, Velankar S, Verlato M, Winn M.   +30 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Effects of Rodent Thermoregulation on Animal Models in the Research Environment. [PDF]

Comp Med, 2018
Hankenson FC, Marx JO, Gordon CJ, David JM.   +3 more
europepmc   +1 more source