Results 161 to 170 of about 5,021,475 (359)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Research ethics committees in Africa: Authors' reply [PDF]
, 2007 Ajuwon, A +12 more
core +3 more sources
Research ethics: ethical review and beyond
Science is a collective endeavor highly dependent on public acceptance and trust. Research findings must be reliable to serve the surrounding society as well as the research community itself. Evidence-based practice and policy recommendations may become ineffective or even dangerous if based on fraudulent research findings.
Elin Palm, Lars Lindblom
openaire +2 more sources
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
DISCUSSION: AGRO-ETHICS -- EXTENSION, RESEARCH, AND TEACHING [PDF]
Teaching/Communication/Extension/Profession,
Coutu, Arthur J.
core +1 more source
Ethiek In En Van Kwalitatief Onderzoek (Book Review: Ethics In Qualitative Research) [PDF]
, 2013 Stefan Verweij
openalex
Managers’ Morality. A Contribution to Business Ethics Research in Postsocialist Serbia [PDF]
, 2015 Jelena Manić Radoičić
openalex +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source