Results 21 to 30 of about 188,864 (309)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Brain drain and distance to frontier [PDF]

, 2006
In this paper we investigate the effects of emigration on growth in developing countries. We present a model in which productivity increases either through imitation or innovation, and both activities use the same types of human capital as inputs, albeit
Stryszowski, P.K., Stryszowski, Piotr, Di Maria, Corrado, Di Maria, C.   +3 more
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Frontier Research on Low-Resource Speech Recognition Technology

Sensors, 2023
With the development of continuous speech recognition technology, users have put forward higher requirements in terms of speech recognition accuracy. Low-resource speech recognition, as a typical speech recognition technology under restricted conditions,
Wushour Slam, Yanan Li, Nurmamet Urouvas
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Remote Sensing-Based Advances in Climate Change Impacts on Agricultural Ecosystem Respiration

Agriculture
Global climate change is exerting a growing impact on agricultural ecosystems. Accurately assessing the spatiotemporal dynamics of agricultural ecosystem respiration and its response mechanisms to climate has therefore emerged as a critical issue in ...
Xingshuai Mei, Tongde Chen, Jianjun Li, Fengqiuli Zhang, Jiarong Hou, Keding Sheng   +5 more
doaj   +1 more source

Development of Human Support Robot as the research platform of a domestic mobile manipulator

ROBOMECH Journal, 2019
There has been an increasing interest in mobile manipulators that are capable of performing physical work in living spaces worldwide, corresponding to an aging population with declining birth rates with the expectation of improving quality of life (QoL).
Takashi Yamamoto, Koji Terada, Akiyoshi Ochiai, Fuminori Saito, Yoshiaki Asahara, Kazuto Murase   +5 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

A Bibliometric Analysis of the Outdoor Thermal Environment Based on CiteSpace

Buildings
The outdoor thermal environment (OTE) is closely related to sustainable urban development and human living, and related research has attracted widespread attention.
Chao Xie, Tangjun Feng, Li Hu
doaj   +1 more source

Psychoneuroimmunology: The new frontier in suicide research

Brain, Behavior, & Immunity - Health, 2021
Elucidating complex, multifactorial phenomena like suicide and suicidal behaviors (SSB) require multidisciplinary fields such as Psychoneuroimmunology (PNI).
Sudan Prasad Neupane
doaj   +1 more source