Results 141 to 150 of about 3,895,024 (310)
COLE and KNOWLES present a book that is simultaneously an introduction to the field, an edited collection of mainly Canadian examples of research issues emerging from the field and a manifesto for arts-informed research.
Volker Wedekind
doaj
International Federation for Research in Women’s History 2024 Conference
Margaret Allen, Ana Stevenson and Michelle Staff share their experiences of attending the 2024 International Federation for Research in Women’s History ...
Allen, Margaret +2 more
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United States Army in the World War, 1917-1919: bulletins, GHQ, AEF, volume 17.
To encourage further research in the history of World War I and to fill a gap in the Army's historical documentation of that conflict, the Center of Military History has created a World War I series of publications consisting of new monographs and ...
Center of Military History
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Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Selection of photos taken at the Witness Seminar “British Contributions to Medicine in Africa after the Second World War” held by the History of Twentieth Century Medicine Group, 03-Jun-1999.
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Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
History of Disseminated Intravascular Coagulation (DIC) Research and My Personal Research History. [PDF]
Iba T.
europepmc +1 more source
Scottish environmental history and the (mis)use of Soums
For much of the historical period pasture was apportioned into relatively small units across much of Europe. Scotland was no exception to this norm and here such units were called soums.
Ross, Alasdair
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