Results 51 to 60 of about 51,114,329 (304)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Moving hotspots [PDF]

open access: yes, 2001
The assumption that stationary hotspots underlie the Earth’s lithospheric plates has been most important in the development of the theory of plate tectonics. According to the fixed hotspot hypothesis seamount trails are formed by volcanism penetrating the
Antretter, Maria
core   +1 more source

Research hotspots and trends in intrinsic capacity of older people in the context of population aging based on CiteSpace

open access: yesFrontiers in Aging
ObjectiveTo employ bibliometrics to identify the research hotspots and development trends of the intrinsic capacity of older people, thereby providing novel insights for future studies on the management of intrinsic capacity in older adults and further ...
Minhua Ren   +5 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

open access: yesMolecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad   +2 more
wiley   +1 more source

Hotspots and Development Trends in Global Mathematics Education Research on a Quantitative Analysis Utilizing the Cite Space Knowledge Map

open access: yesJournal of Social Sciences and Economics, 2023
Utilizing the literature from the Web of Science Core Collection database spanning the years 2013-2023 as a sample, this study employs the bibliometric tool CiteSpace to analyze publication quantity, countries, research institutions, journals, and ...
Lei Li, Yu Tang
doaj   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

open access: yesMolecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler   +3 more
wiley   +1 more source

Unveiling the complex networks of urban tree diversity research: A global perspective

open access: yesEcology and Evolution
Ecosystem services offered by urban forests must be proactively managed to remain diverse and sustainable. Recent research findings deserve a systematic synthesis to elucidate inherent knowledge structures and dynamics.
Chunping Xie   +3 more
doaj   +1 more source

Analysis and Prospect of Soil Organic Carbon Research Process in Recent 30 Years at Home and Abroa

open access: yesShuitu baochi yanjiu, 2020
Citespace bibliometrics software was used to sort out the literature regarding soil organic science in Web of Science and CNKI. By analyzing the frequency, centrality and clustering of keywords, and mutation words, we clarify the development of soil ...
ZHOU Mi   +6 more
doaj  

Manifesto for medical research [PDF]

open access: yes, 2015
The MRCG want to ensure there is a dynamic medical research environment in Ireland. Ensuring priority investment for medical research will help to deliver patient care, public health service transformation and economic and enterprise development.
Medical Research Charities Group
core  

Renewal through health research: HRCI position paper 2021

open access: yes, 2021
On January 28th we launched our 2021 position paper: Renewal through health research. It lays out a series of critical health research actions to help create a post-Covid Ireland where healthcare is world-class and based on evidence. It calls for:
Health Research Charities Ireland, /
core  

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