Results 191 to 200 of about 50,210,574 (305)

A curated structural dataset of peptide-protein complexes reveals biases in existing datasets and principles of peptide binding. [PDF]

Protein Sci
Hamdani R, Delgado J, Serrano L.
europepmc   +1 more source

Deep Learning‐Driven Discovery and Engineering of an Efficient PETase for Depolymerization and Detoxification of PET Microplastics Under Physiological Conditions

Advanced Science, EarlyView.
A deep learning–driven pipeline mining 246 million protein sequences uncovers AhPETase, an evolutionarily distinct PET hydrolase. Engineered variant AhPETaseM1 degrades post‐consumer PET microplastics under physiological conditions and reverses microplasticinduced cytotoxicity in human lung and colon cells, establishing enzymatic microplastic ...
Yuxuan Wang, Shijie He, Yuheng Chang, Sheng Mao, Jianan Canal Li, Binbin Chen, Hongxun Gao, Mingchun Xu, Chenxu Liu, Yajie Wang   +9 more
wiley   +1 more source

Correction: Multimodal sequencing identifies synergistic mechanisms driving resistance to neoadjuvant nivolumab treatment in hepatocellular carcinoma. [PDF]

Mol Cancer
Zeng F, Guo J, Zeng Z, Zhang VX, Tsui YM, Li PM, Husain A, Zhang Q, Lee JM, Cheung TT, Ho DW, Ng IO.   +11 more
europepmc   +1 more source

Convergence of Plasmid‐Mediated tmexCD‐toprJ With Critical Resistance Genes Fuels Spread of Multidrug Resistant Bacteria

Advanced Science, EarlyView.
Global dissemination of tmexCD‐toprJ across bacterial hosts and ecological niches is accompanied by its convergence with blaKPC, blaNDM, and mcr on mobile plasmids. Recombination and acquisition of resistance modules generate distinct multidrug resistant plasmid architectures, facilitating the emergence and spread of high‐risk bacterial populations ...
Kaiwen Song, Meng Wang, Xingyu Wu, Meng Cai, Bowen Li, Qi Wang, Xiaodong Guan, Qi Ding, Ruobing Wang, Hui Wang   +9 more
wiley   +1 more source

Molecular subtyping and POLE mutation spectrum in endometrial carcinoma. [PDF]

Indian J Med Res
Uppin M, Thomas DM, Shantappa R, Konatam ML, Ratnagiri R, Puranum K, Razzak K, Uppin SG.   +7 more
europepmc   +1 more source

Topology‐Enabled Finite‐Band Absorption Framework Based on a Bioinspired Nested Dual‐Loop Architecture

Advanced Science, EarlyView.
A nuclear‐pore‐inspired nested dual‐loop architecture redistributes electromagnetic energy through coupled transport, confinement, and dissipation pathways. Integrated with Co/Fe3O4 dual‐magnetic composites and topology optimization, the 11‐mm‐thick absorber delivers continuous 2–40 GHz attenuation, raises finite‐band structural utilization to 82%, and
Shaokang Liu, Weicheng Liao, Pinchen Luo, Mengchen Jin, Tangming Yan, Xing Zhao, Qingshan Wang   +6 more
wiley   +1 more source

MRE11 suppresses germline mutagenesis at meiotic double-strand breaks in mice. [PDF]

Genes Dev
Lukaszewicz A, Wilson TE, Kim S, Keeney S, Jasin M.   +4 more
europepmc   +1 more source

Quantitative Navigated Transcranial Magnetic Stimulation Motor Mapping and nTMS-Guided Corticospinal Tractography in Healthy Individuals and Patients with Motor-Eloquent Brain Tumors. [PDF]

Brain Sci
Chatzikyriakou E, Vlachos I, Pastiadis K, Foroglou N, Kouskouras K, Feretos G, Frantzidis C, Patsalas I, Papaliagkas V, Kugiumtzis D, Kimiskidis VK.   +10 more
europepmc   +1 more source

A Synthetic Platform for Antibody Junctional Diversification Beyond Natural Constraints

Advanced Science, EarlyView.
ARESEC is a synthetic platform that reconstructs functional V(D)J recombination in HEK293T cells. By introducing RSS elements and co‐expressing RAG1/2 and TdT across all three antibody CDRs, it enables programmable junctional diversification and direct generation of high‐affinity variants targeting PD‐1/PD‐L1, overcoming the evolutionary constraints of
Wang Liu, Jun Yang, Yuhang Zhang, Xiaoli Xue   +3 more
wiley   +1 more source

Liquid Biopsy-Based Profiling of <i>TP53</i> Gene Hotspot Mutations in HBV-Induced Chronic Liver Disease and Hepatocellular Carcinoma Patients: A Study From Bangladesh. [PDF]

Int J Hepatol
Akter S, Sultana S, Noman MZI, Laila F, Nessa A.   +4 more
europepmc   +1 more source