Results 41 to 50 of about 51,114,329 (304)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Hotspot Zuidplaspolder: Climate adaptation in the Zuidplaspolder [PDF]
, 2008 Building at the lowest point in the Netherlands, in the Zuidplaspolder, is viewed as a challenge and not something that is impossible. The Xplorelab approach in the Hotspot Zuidplaspolder project is a combination of research, implementation of ideas into
Pelt, F., van +5 more
core
Distribution maps of endemic Caspian Sea mollusks in hotspot and non-hotspot areas
, 2019 The Caspian Sea is renowned for its endemic mollusk biodiversity. However, over the past decades, increasing anthropogenic pressures have caused decreases in abundances and even extinction of species.
Lattuada, Matteo +7 more
core +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Pembangunan Spatiotemporal Data Model Pada Data Hotspot Dengan Konsep Event-based Spatiotemporal Data Model (ESTDM) [PDF]
, 2011 Hotspot data that has been existed all this time is still in the form of usual spatial data which is not enough to keep temporal information and information about how a hotspot evolved.
Kurniawan, Yuridhis
core
Conservation Businesses and Conservation Planning in a Biological Diversity Hotspot [PDF]
, 2013 The allocation of land to biological diversity conservation competes with other land uses and the needs of society for development, food, and extraction of natural resources.
MacMillan, Douglas C.
core +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Research hotspots and future trends of hot corrosion research: a bibliometric analysis
RSC Advances, 2023 Knowledge map of hot corrosion research: six research hotspots of the hot corrosion research field were elucidated.
Andrieanto Nurrochman +4 more
openaire +2 more sources
Frontiers in OncologyObjectiveTo explore the current status of therapeutic drug monitoring (TDM) research on anticancer drugs, analyze research hotspots and trends, and provide insights and references for future studies.MethodsData were retrieved from the Web of Science Core
Can Qian +9 more
doaj +1 more source