Results 151 to 160 of about 106,644 (264)

SPADE: A Deep Learning Framework for Spatial Mapping and Quantitative Cell–Cell Interaction Inference

Advanced Science, EarlyView.
SPADE integrates spatial transcriptomics with single‐cell RNA sequencing by using cell–cell communications (CCC) as a guide for spatial mapping. It improves cell‐type localization, enhances sparse gene‐expression signals, and reveals CCC programs at single‐spot resolution.
Xinyi Li, Ning Zhang, Zijie Jin
wiley   +1 more source

Stiffness‐Activated Stellate Cells Drive Pancreatic Cancer Liver Colonization via GMFG‐TNS4 Signaling

Advanced Science, EarlyView.
Fibrotic liver stiffness activates hepatic stellate cells through Piezo1‐dependent calcium influx and ER stress, promoting EV‐associated GMFG release. Delivered GMFG engages TNS4 in pancreatic cancer cells, triggering FAK/AKT signaling, adhesion, and fatty acid synthesis.
Biwen Zhu, Jian Wan, Xue Zhang, Jiashuai Yan, Xi Chen, Xiaoqi Guan, Qianqian Ren, Tao Yang, Di Wu, Qingsong Guo, Yibing Guo, Yuhua Lu   +11 more
wiley   +1 more source

Research Hotspots and Trend Analysis of Barrier Dam Break Mechanism

Renmin Zhujiang
To comprehensively evaluate the research status and analyze the research hotspot and development trend of barrier dam break, this paper uses CitsSpace to analyze the number of publications, institutional authors, and keywords of research literature on ...
LI Yan'ang, HAN Peifeng, HUANG Shijie, YANG Guocheng, GONG Yukai, LIU Rui   +5 more
doaj  

Mutational landscape and molecular bases of echinocandin resistance in Saccharomyces cerevisiae. [PDF]

Genetics
Durand R, Torbey AG, Giguere M, Pageau A, Dubé AK, Lagüe P, Landry CR.   +6 more
europepmc   +1 more source

Targeting Lipopolysaccharide Transport Induces Membrane Lipid Remodeling and Sensitizes Acinetobacter baumannii to Colistin Treatment

Advanced Science, EarlyView.
This study identifies C4 as a lead inhibitor of the Lpt system. Notably, C4 potentiates colistin activity by disrupting LPS transport and remodeling phospholipid homeostasis, revealing a functional interplay between the Lpt and Mla systems. These findings establish a mechanistic link between Lpt inhibition and membrane lipid remodeling, positioning Lpt–
Jianya Luo, Hetianzi Zhang, Jinju Cai, Shuang Zhou, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +6 more
wiley   +1 more source

Ki-67 Quantification in Breast Cancer: A Comparison of Hotspot and Global Scoring Methods Using a Standardized Android Application. [PDF]

Cureus
Patel M, Jawalkar S.
europepmc   +1 more source

De Novo Designed Minibinders Targeting the GDF15–GFRAL Axis Reverse Cancer Cachexia and Restore Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐derived GDF15 drives cancer cachexia and suppresses antitumor immunity. Here, de novo designed minibinders targeting the GDF15–GFRAL interface achieve picomolar affinity and potent pathway blockade. The minibinders alleviate cachexia, restore CD8+ T‐cell infiltration, enhance anti–PD‐1 responsiveness, and provide survival benefits across tumor ...
Haitao Wang, Tianzhen Hua, Meiling Wang, Bingbing Meng, Yue Zhang, Chengxu Jiang, Yunhe Gao, Hongqi Yang, Jian Bo   +8 more
wiley   +1 more source

Panel-negative strategy for suspected fusion-driven papillary thyroid carcinoma. [PDF]

Thyroid Res
Okubo Y, Takada I, Kadoya M, Toda S, Wada S, Masudo K, Miyagi Y, Hayashi H.   +7 more
europepmc   +1 more source

Correcting Apparent Priming Bias Unveils Fertilizer Nitrogen‐Risk Archetypes of Surplus and Depletion Across Asian Rice Systems

Advanced Science, EarlyView.
Correcting the apparent priming effect resolves systematic biases in Asian rice fertilizer nitrogen accounting. Net soil retention drops below 7%, while 48% of fertilizer escapes, inflicting US$98.53 billion in annual reactive‐nitrogen damages. High‐resolution mapping uncovers N‐risk archetypes across 42% of the rice area, delivering a spatially ...
Xiuyun Liu, Siyuan Cai, Longlong Xia, Jagdish K. Ladha, Xiaoyuan Yan, Xu Zhao   +5 more
wiley   +1 more source

The Green Parkinson's Belt: agricultural regions associated with increased Parkinson's disease burden in Mexico. [PDF]

Front Aging Neurosci
Martinez HR, Luna-Rangel FA, Gonzalez-Bedolla B, Armengol-Garcia C, Rebolledo-Garcia D, Rodriguez BL, Figueroa-Sanchez JA.   +6 more
europepmc   +1 more source