Results 91 to 100 of about 107,666 (263)

Placental Site Trophoblastic Tumor Acquires Immune Functions by Incorporating Host Maternal Genes

Advanced Science, EarlyView.
PSTT cells, through cell fusion with B cells, incorporate abundant non‐inherited maternal genes that are detectable by DNIMA. These hybrid cells acquire immunotherapy‐resistant genetic changes and increase the expression of B cell‐derived immune‐related molecules such as Ig, HLA, LILRB, SIGLEC10, and so on, creating an immunotolerant environment around
Kyosuke Kagami, Masanori Ono, Yasunari Mizumoto, Tatsuhito Kanda, Takashi Iizuka, Takiko Daikoku, Shin‐ichi Horike, Akira Hattori, Akihito Horie, Sachiko Minamiguchi, Tomoko Fujiwara, Kazuyoshi Hosomichi, Atsushi Tajima, Hirokazu Usui, Kaoru Abiko, Hiroshi Fujiwara   +15 more
wiley   +1 more source

Knowledge graph and emerging trends in oxidative stress research on hepatic ischemia-reperfusion injury: a bibliometric analysis (1995–2024)

Frontiers in Pharmacology
BackgroundHepatic ischemia-reperfusion injury (HIRI) is a common complication in surgical procedures such as liver transplantation and extensive hepatectomy, characterized by an ischemic or hypoxic phase followed by reperfusion.
Simeng Lei, Yangkai Fu, Bo Zhang, Hanwen Yang, Zhili Ji   +4 more
doaj   +1 more source

A Phase‐Resolved Geometric Deep Learning Framework Maps Structural Determinants of Disease‐Associated Protein Aggregation and Guides Suppressor Design

Advanced Science, EarlyView.
SKALE 2.0 maps disease‐associated protein aggregation as a phase‐resolved structural process, linking mutation‐induced geometric perturbations to nucleation, elongation, and suppressor design. Across neurodegenerative proteins, the framework reveals cryptic aggregation vulnerabilities, separates phase‐concordant and phase‐switching mutations, and ...
Jia Shen Sio, Wei Xuan Wilson Loo, Yan Shan Loo, Wen Xin Tan, Hui Xuan Lim, Huitao Liu, Chen Seng Ng   +6 more
wiley   +1 more source

Research Progress on Hotspots and Trends of Eco-hydrology

Renmin Zhujiang
Eco-hydrology is an interdisciplinary field that combines ecology and hydrology, primarily focusing on the interactions between water and ecosystems on Earth. To explore the current state and hotspots of research in the field of eco-hydrology, this study
HUANG Wei, JI Yong, WANG Pengyang, LI Zhuojun, ZHANG Jie, YE Fangqi   +5 more
doaj  

SPADE: A Deep Learning Framework for Spatial Mapping and Quantitative Cell–Cell Interaction Inference

Advanced Science, EarlyView.
SPADE integrates spatial transcriptomics with single‐cell RNA sequencing by using cell–cell communications (CCC) as a guide for spatial mapping. It improves cell‐type localization, enhances sparse gene‐expression signals, and reveals CCC programs at single‐spot resolution.
Xinyi Li, Ning Zhang, Zijie Jin
wiley   +1 more source

Stiffness‐Activated Stellate Cells Drive Pancreatic Cancer Liver Colonization via GMFG‐TNS4 Signaling

Advanced Science, EarlyView.
Fibrotic liver stiffness activates hepatic stellate cells through Piezo1‐dependent calcium influx and ER stress, promoting EV‐associated GMFG release. Delivered GMFG engages TNS4 in pancreatic cancer cells, triggering FAK/AKT signaling, adhesion, and fatty acid synthesis.
Biwen Zhu, Jian Wan, Xue Zhang, Jiashuai Yan, Xi Chen, Xiaoqi Guan, Qianqian Ren, Tao Yang, Di Wu, Qingsong Guo, Yibing Guo, Yuhua Lu   +11 more
wiley   +1 more source

Research Hotspot and Trend Analysis of Earth-Rockfill Dam Stability Based on Knowledge Map

Renmin Zhujiang
Since the 20th century, earth-rockfill dam instability accidents have occurred frequently all over the world. In order to systematically summarize the current status and hotspots of research on earth-rockfill dam stability and analyze the future ...
WANG Luoxi, HAN Peifeng, LI Yan'ang, YANG Guocheng, QIU Hongzhi   +4 more
doaj  

Evolution Trend of Brain Science Research: An Integrated Bibliometric and Mapping Approach

Brain and Behavior
Background Brain science research is considered the crown jewel of 21st‐century scientific research; the United States, the United Kingdom, and Japan have elevated brain science research to a national strategic level.
Sujuan Zhang, Jingyan Gu, Yang Yang, Jiangan Li, Lulu Ni   +4 more
doaj   +1 more source

Research advances and hotspot analysis on systematic review and Meta analysis in international nursing field

Huli yanjiu, 2020
ObjectiveTo analyze research advance and hotspots of systematic reviews and Meta analyses in international nursing field，so as to provide references for development of evidence⁃based nursing research in China.MethodsPubMed and Web of Science databases ...
LI Zhen, LI Qi, LI Zunzhu, SUN Jianhua, LUO Hongbo, DENG Haibo, SHENG Yu   +6 more
doaj  

A bibliometric analysis of brucellosis research (1991–2022): Research trends and hotspots

South African Journal of Animal Science
Brucellosis is an important, highly contagious, bacterial zoonotic disease that has economic and public health implications. It is caused by various Brucella species with a wide host range including livestock, wildlife, other terrestrial animals, and humans.
Farooq, M., Khan, A.U., El-Adawy, H., Melzer, F., Neubauer, H., Khan, I., Ho, Y.-S.   +6 more
openaire   +3 more sources