Results 91 to 100 of about 106,704 (264)

Chemoproteomic Identification of AKT2 as a Paclitaxel‐Binding Protein via C─C Bond‐Linked Probe PTX‐4 in Paclitaxel‐Resistant Breast Cancer

Advanced Science, EarlyView.
ABSTRACT Breast cancer remains one of the most prevalent malignancies among women, and taxane‐based chemotherapies such as paclitaxel and docetaxel are central to standard treatment regimens. However, drug resistance in breast cancer limits therapeutic efficacy and contributes to recurrence and metastasis.
Kai Wang, Yuqing Yuan, Wei Shen, Xiuxiu Yang, Xiaokang Wu, Haihua Zhou, Yi Hu, Qing Zhu   +7 more
wiley   +1 more source

Knowledge graph and emerging trends in oxidative stress research on hepatic ischemia-reperfusion injury: a bibliometric analysis (1995–2024)

Frontiers in Pharmacology
BackgroundHepatic ischemia-reperfusion injury (HIRI) is a common complication in surgical procedures such as liver transplantation and extensive hepatectomy, characterized by an ischemic or hypoxic phase followed by reperfusion.
Simeng Lei, Yangkai Fu, Bo Zhang, Hanwen Yang, Zhili Ji   +4 more
doaj   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Research hotspots and development trends in the stalagmite field from 2015 to 2024 based on CiteSpace

Carsologica Sinica
Stalagmites are regarded as the fourth pillar for studying paleoclimatology and serve as important geological carriers for paleoclimate research. In recent years, there have been few studies in China that utilize CiteSpace software for the quantitative ...
Wenming ZHOU, Xunlin YANG, Sinan WANG, Linju WANG, Guofeng LI, Wanli XIANG, Xiaoyan GE, Meng GONG   +7 more
doaj   +1 more source

Recent Advances in Laser‐Induced Graphene‐Based Gas Sensors: From Sensing Mechanisms to Biomedical Applications

Advanced Science, EarlyView.
Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Md Abu Sayeed Biswas, Ankan Dutta, Shuvendu Das, Abu Musa Abdullah, Wanqing Zhang, Fatema Tuz Zohra, Huanyu Cheng   +6 more
wiley   +1 more source

Research Progress on Hotspots and Trends of Eco-hydrology

Renmin Zhujiang
Eco-hydrology is an interdisciplinary field that combines ecology and hydrology, primarily focusing on the interactions between water and ecosystems on Earth. To explore the current state and hotspots of research in the field of eco-hydrology, this study
HUANG Wei, JI Yong, WANG Pengyang, LI Zhuojun, ZHANG Jie, YE Fangqi   +5 more
doaj  

Extreme Polaritonic Interactions in a Room‐Temperature Designable Sub‐Nanocavity Quantum Electrodynamic Platform

Advanced Science, EarlyView.
 A nanoparticle‐cluster‐on‐mirror (NPcoM) serves as a functionally deterministic sub‐nanocavity that emulates picocavities, enabling extreme light–matter interactions and polaritonic phenomena. ABSTRACT Pushing nanoscale optical confinement to its ultimate limits defines the regime of nano‐cavity quantum electrodynamics (nano‐cQED), where light‐matter ...
Huatian Hu, Xin Shu, Zhiwei Hu, Di Zheng, Ruiqian Zhang, Ximin Cui, Wei Dai, Xiang Lan, Xiaobo Han, Wen Chen, Hongxing Xu   +10 more
wiley   +1 more source

Evolution Trend of Brain Science Research: An Integrated Bibliometric and Mapping Approach

Brain and Behavior
Background Brain science research is considered the crown jewel of 21st‐century scientific research; the United States, the United Kingdom, and Japan have elevated brain science research to a national strategic level.
Sujuan Zhang, Jingyan Gu, Yang Yang, Jiangan Li, Lulu Ni   +4 more
doaj   +1 more source

A bibliometric analysis of brucellosis research (1991–2022): Research trends and hotspots

South African Journal of Animal Science
Brucellosis is an important, highly contagious, bacterial zoonotic disease that has economic and public health implications. It is caused by various Brucella species with a wide host range including livestock, wildlife, other terrestrial animals, and humans.
Farooq, M., Khan, A.U., El-Adawy, H., Melzer, F., Neubauer, H., Khan, I., Ho, Y.-S.   +6 more
openaire   +3 more sources

FUCA2 Sustains AKT Signaling and Suppresses Senescence by Antagonizing FUT3‐Mediated ErbB3 Fucosylation in Lung Adenocarcinoma

Advanced Science, EarlyView.
ABSTRACT While targeted therapies have improved outcomes in lung adenocarcinoma (LUAD), many patients still lack targetable mutations. Here, we identified alpha‐L‐fucosidase 2 (FUCA2) as a crucial driver of LUAD by preventing cellular senescence. Mechanistically, through the restriction of fucosyltransferase 3 (FUT3)‐mediated α‐1,3‐fucosylation of ...
Lu Chen, Jintao Guo, Fei Li, Mingjie Gao, Runyang Li, Zhaozhang Huang, Yaolin Zheng, Chunyi Gao, Jihuan Hou, Qiang Yu, Bowen Zheng, Xuemei Chen, Wenqing Zhang, Xiaoting Hong, Yali Zheng, Daxuan Wang, Qiyuan Li, Tianhui Hu, Yan‐yan Zhan   +18 more
wiley   +1 more source