Results 101 to 110 of about 107,666 (263)

Targeting Lipopolysaccharide Transport Induces Membrane Lipid Remodeling and Sensitizes Acinetobacter baumannii to Colistin Treatment

Advanced Science, EarlyView.
This study identifies C4 as a lead inhibitor of the Lpt system. Notably, C4 potentiates colistin activity by disrupting LPS transport and remodeling phospholipid homeostasis, revealing a functional interplay between the Lpt and Mla systems. These findings establish a mechanistic link between Lpt inhibition and membrane lipid remodeling, positioning Lpt–
Jianya Luo, Hetianzi Zhang, Jinju Cai, Shuang Zhou, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +6 more
wiley   +1 more source

Research hotspots and development trends in the stalagmite field from 2015 to 2024 based on CiteSpace

Carsologica Sinica
Stalagmites are regarded as the fourth pillar for studying paleoclimatology and serve as important geological carriers for paleoclimate research. In recent years, there have been few studies in China that utilize CiteSpace software for the quantitative ...
Wenming ZHOU, Xunlin YANG, Sinan WANG, Linju WANG, Guofeng LI, Wanli XIANG, Xiaoyan GE, Meng GONG   +7 more
doaj   +1 more source

De Novo Designed Minibinders Targeting the GDF15–GFRAL Axis Reverse Cancer Cachexia and Restore Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐derived GDF15 drives cancer cachexia and suppresses antitumor immunity. Here, de novo designed minibinders targeting the GDF15–GFRAL interface achieve picomolar affinity and potent pathway blockade. The minibinders alleviate cachexia, restore CD8+ T‐cell infiltration, enhance anti–PD‐1 responsiveness, and provide survival benefits across tumor ...
Haitao Wang, Tianzhen Hua, Meiling Wang, Bingbing Meng, Yue Zhang, Chengxu Jiang, Yunhe Gao, Hongqi Yang, Jian Bo   +8 more
wiley   +1 more source

Visualization Analysis of Research Status and Hot Spots of Phosphine Based on CiteSpace (2004—2023)

Liang you shipin ke-ji
Phosphine plays an important role in chemistry, materials science, physics, agriculture and other fields, and is widely used in semiconductor, plastic industry and storage fumigation. In order to systematically sort out the research hotspots of phosphine
ZHANG Hui-yan, LI Yan-yu, ZI Jia-yu, CHEN Xin, CUI Peng-cheng, ZHOU Gui-ming, TAO Hai-hua, TIAN Xiao-wei   +7 more
doaj   +1 more source

A Metal‐Phenolic Nanocluster Orchestrates Mito‐Ca2+ Metabolic Autonomy for Tumor Ca2+ Interference Therapy

Advanced Science, EarlyView.
Tumor Ca2+ interference therapy suffers from self‐protective Ca2+ metabolic autoregulation. In this scenario, a versatile metal‐phenolic nanocluster (TCMH) is engineered to modulate mitochondrial calcium uniporter (MCU) ‐mediated mito‐Ca2+ metabolic autonomy.
Ronglong Chen, Jia Huang, Yuepeng Wang, Shucong Yao, Fei Wu, Juan Liu, Chunxue Song, Li Lin, Xijun Lin, Yingjie Deng, Chao Zhang, Zhiquan Huang, Zixian Huang, Lisi Xie   +13 more
wiley   +1 more source

Massage in the application of perioperative medicine: research hotspots and trends

Frontiers in Medicine
BackgroundOver the past decade, the application of massage in the perioperative period has attracted the interest of researchers worldwide, with a relatively stable volume of literature published annually.ObjectiveBy conducting a bibliometric analysis of the literature from the past decade, this study aims to identify the research overview, hotspots ...
Xiaoqin Li, Chuan You, Haige Wei, Huan Li, Yun Liang, Yun Liang   +5 more
openaire   +3 more sources

Closed‐Loop Decoding and Intervention of Pain: A Novel BMI Strategy Integrating θ‐Band Detection and Mechano‐Electro‐Biological Coupled Hydrogels

Advanced Science, EarlyView.
A closed‐loop brain–machine interface with a PFAPT hydrogel electrode identifies prefrontal θ‐band as a neuropathic pain biomarker. The hydrogel enables stable 28 d ECoG recording and delivers θ‐triggered cortical stimulation, alleviating pain and affective behaviors in rats via bidirectional regulation of inflammation and central sensitization ...
Yun Ji, Tao Li, Guoqiang Lei, Huichun Luo, Xiuqian Guo, Jiao Xiang, Tao Shi, Weitang Liu, Yuxin Zhang, Xiaoyu Liao, Shutao Zhao, Jiayun Wu, Wangao Zhang, Wenhui Liu, Chuanglong He, Shuo Chen, Tao Wu, Ke Ma   +17 more
wiley   +1 more source

Research hotspots and frontiers of alcohol and epilepsy: A bibliometric analysis

Neuropsychopharmacology Reports
AbstractPurposeAlcohol is implicated in epileptogenesis and seizures attack. An increasing number of studies about alcohol and epilepsy have been published. We aimed to assess research trends and hot spots in the field of alcohol and epilepsy.Patients and MethodsLiterature concerning alcohol and epilepsy was systemically searched through the Web of ...
Wenhui Liu, Huan Li, Simei Lin
openaire   +3 more sources

Hypergolic Copper Cluster‐Based Covalent Organic Frameworks

Advanced Science, EarlyView.
Hpergolic cluster‐based covalent organic framework (Cu3‐CB‐COF), assembled from aldehyde‐functionalized carborane monomers and trinuclear copper clusters, demonstrates a strong synergy between its catalytic copper nodes and energetic carborane backbones.
Yu‐Zhou Qiao, Cai Li, Wen‐Yang Jiao, Guoqiang Sun, Xiao‐Fei Liu, Shuang‐Quan Zang   +5 more
wiley   +1 more source

Bibliometric analysis of nursing theory related research based on CNKI database

Huli yanjiu, 2022
ZHU Ruifang, WANG Yaping, HAN Shifan, DUAN Zhiguang   +3 more
doaj