Results 241 to 250 of about 281,215 (305)

Disrupting Child Sexual Exploitation in New South Wales: A Mixed‐Method Survey Exploring Workforce Capacities

open access: yesAustralian Journal of Social Issues, EarlyView.
ABSTRACT Child sexual exploitation (CSE) is an insidious form of child sexual abuse (CSA) that impacts Australia's most vulnerable children and young people. Reports of CSE abuses experienced by children and young people living in out‐of‐home care (OOHC) have spurred urgent calls for improving responses to CSE in Australia.
Sarah Ciftci   +2 more
wiley   +1 more source

Molecular characterization of the A52 murine hepatocellular carcinoma cell line

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Hepatocellular carcinoma (HCC) is a poor outcome cancer with limited therapeutic choices. To advance therapeutic development we genetically characterized the A52 murine HCC cell line. We noted genetic changes that match a subset of human HCC and this offers the opportunity to test novel targeted therapies in syngeneic mice.
Rhys Gillman   +5 more
wiley   +1 more source

The Clinical Spectrum and Neurodevelopmental Pathogenesis of KPTN‐Related Disorder in a Mouse Model

open access: yesAnnals of Neurology, EarlyView.
Objective Pathogenic variants in Kaptin (KPTN) cause KPTN‐related disorder (KRD). KPTN modulates mTOR signaling activation within the KICSTOR complex in response to cellular amino acid levels. We define the clinical spectrum and investigate the developmental pathogenesis of KRD.
Lettie E. Rawlins   +104 more
wiley   +1 more source

Engineering Tertiary Lymphoid Structures: Nanomedicine, Bioengineering, and Biomaterials for Precision Immunotherapy

open access: yesAdvanced NanoBiomed Research, EarlyView.
This review explains how biomaterials and nanoparticles can be used to induce or modulate tertiary lymphoid structures (TLSs), which are ectopic immune hubs that form in nonlymphoid tissues during chronic disease and cancer. By comparing different methods, the article highlights design principles for modeling TLSs or recapitulating specific TLS ...
Shaza Karaman, Mei ElGindi, Jeremy Teo
wiley   +1 more source

Research hotspots and trends of thoracic analgesia from 1994 to 2023: a bibliometric analysis. [PDF]

open access: yesFront Surg
Meng Y   +10 more
europepmc   +1 more source

Macromolecular Condensates as Tunable Scaffolds for Bio‐Inspired Silica Hybrids

open access: yesAngewandte Chemie, EarlyView.
Dense bio‐inspired silica formation is achieved by coupling polyamine liquid–liquid phase separation with pH‐dependent silica polymerization. Silicification within polyamine condensates, enables precise control over particle size, density, and morphology.
Protap Biswas   +6 more
wiley   +1 more source

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