Results 161 to 170 of about 30,282,823 (310)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Education Research: Impact of Burnout on Neurology Residents and Research Fellows in Europe. [PDF]

Neurol Educ, 2022
Di Liberto G, Baldizzi G, Carvalho V, Cuffaro L, Sauerbier A, Klingelhoefer L, Vashchenko N, Pavlakova L, Sander A, de Visser M, Boon PAJM, Moro E, Bassetti C.   +12 more
europepmc   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Harnessing the nursing and midwifery workforce to boost Australia's clinical research impact. [PDF]

Med J Aust, 2022
Eckert M, Rickard CM, Forsythe D, Baird K, Finn J, Gilkison A, Gray R, Homer CS, Middleton S, Neville S, Whitehead L, Sharplin GR, Keogh S.   +12 more
europepmc   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Linguistic positivity in soft and hard disciplines: temporal dynamics, disciplinary variation, and the relationship with research impact. [PDF]

Scientometrics, 2023
Liu X, Zhu H.
europepmc   +1 more source

Arctic Research Impact

, 2022
NordForsk has together with the national research funders in the Nordics financed four large Nordic Centres of Excellence on Arctic research. This report summarises the results from the centres. The number of publications, disseminations and other outcomes are impressive.
openaire   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

How to … Maximise Your Clinical Education Research Impact. [PDF]

Clin Teach
Sims DA, Sandars J, Wong WYA, Samuriwo R, Burford B.   +4 more
europepmc   +1 more source

A research intelligence approach to assess the research impact of the Dutch university medical centres. [PDF]

Health Res Policy Syst, 2022
Iping R, Kroon M, Steegers C, van Leeuwen T.   +3 more
europepmc   +1 more source