Results 61 to 70 of about 50,249,813 (232)

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

PAN EURASIAN EXPERIMENT (PEEX) - A RESEARCH INITIATIVE MEETING THE GRAND CHALLENGES OF THE CHANGING ENVIRONMENT OF THE NORTHERN PAN-EURASIAN ARCTIC-BOREAL AREAS

Geography, Environment, Sustainability, 2014
The Pan-Eurasian Experiment (PEEX) is a new multidisciplinary, global change research initiative focusing on understanding biosphere-ocean-cryosphere-climate interactions and feedbacks in Arctic and boreal regions in the Northern Eurasian geographical ...
Hanna K. Lappalainen, Tuukka Petäjä, Joni Kujansuu, Veli-Matti Kerminen, Anatoly Shvidenko, Jaana Bäck, Timo Vesala, Timo Vihma, Gerrit De Leeuw, Antti Lauri, Taina Ruuskanen, Vladimir B. Lapshin, Nina Zaitseva, Olga Glezer, Mikhail Arshinov, Dominick V. Spracklen, Steve R. Arnold, Sirkku Juhola, Heikki Lihavainen, Yrjö Viisanen, Natalia Chubarova, Sergey Chalov, Nikolay Filatov, Andrey Skorokhod, Nikolay Elansky, Egor Dyukarev, Igor Esau, Pertti Hari, Vladimir Kotlyakov, Nikolay Kasimov, Valery Bondur, Gennady Matvienko, Alexander Baklanov, Evgeny Mareev, Yuliya Troitskaya, Aijun Ding, Huadong Guo, Sergej Zilitinkevich, Markku Kulmala   +38 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

From Project Cycles to Collective Governance: Sustaining Digital Research Infrastructures through the GKFI

Bibliothek
The sustainability of digital research infrastructures (RIs) beyond project-based funding cycles poses significant structural and economic challenges for memory institutions.
Buddenbohm Stefan, Deicke Aline, Kurzawe Daniel, Rapp Andrea, Rißler-Pipka Nanette, Schneider Roman, Weimer Lukas   +6 more
doaj   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Attracting Serendipity: the Impact of Investment at the Science/Technology Interface in Fundamental Physics Research Infrastructures

CERN IdeaSquare Journal of Experimental Innovation
A socio-economic study, the Comparative Analysis of Socio-Economic Impact (CASEIA), developed an analytical framework and methodology for better understanding the socio-economic impact of ATTRACT.
Michael Gastrow, Sonia Utermann, Arne Jungstand, Ulrich Schmoch   +3 more
doaj   +1 more source

Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1

FEBS Open Bio, EarlyView.
The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn, Artur Osyczka, Marcin Sarewicz   +2 more
wiley   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

The Italian effort toward a coordinated observation of Essential Variables (EOV, ECV, EBV) in European Marine Environments. Long-term observation in the central Mediterranean seas and Italian coasts

Frontiers in Marine Science
Monitoring Essential Ocean, Climate, and Biodiversity Variables (EOVs, ECVs and EBVs) collected through the marine Research Infrastructures (RIs) is critical for assessing environmental status, improving scientific knowledge and defining environmental ...
Simone Toller, Emilio Urbinati, Debora Bellafiore, Caterina Bergami, Francesca De Pascalis, Marcello G. Magaldi, Marco Bellacicco, Federico Bellati, Maristella Berta, Angelo Boccacci, Roberto Bozzano, Fabio Brunetti, Giuseppa Buscaino, Carolina Cantoni, Vanessa Rossana Cardin, Carmela Caroppo, Lorenzo P. Corgnati, Alessio Corsi, Silvio Davison, Giuseppe Denti, Andrea Di Macco, Davide Embriaco, Michele Giani, Santina Giandomenico, Giordano Giorgi, Zoi Kokkini, Giovanni La Forgia, Daniele Lagomarsino-Oneto, Carlo Mantovani, Simone Marini, Elena Mauri, Emanuele Organelli, Francesco Paladini De Mendoza, Elena Bianca Papale, Sara Pensieri, Antonella Petrocelli, Jaime Pitarch, Angela Pomaro, Giorgio Riccobene, Francesco Riminucci, Francesco Riminucci, Fernando Rubino, Gian Marco Scarpa, Katrin Schroeder, Roberta Sciascia, Riccardo Tagliavini, Rosalia Santoleri   +46 more
doaj   +1 more source